dc.contributor.author
Gül-Klein, Safak
dc.contributor.author
Sinn, Marianne
dc.contributor.author
Jurmeister, Philipp Sebastian
dc.contributor.author
Biebl, Matthias
dc.contributor.author
Weiß, Sascha
dc.contributor.author
Rau, Beate
dc.contributor.author
Bläker, Hendrik
dc.contributor.author
Pratschke, Johann
dc.contributor.author
Aigner, Felix
dc.date.accessioned
2019-04-18T09:37:37Z
dc.date.available
2019-04-18T09:37:37Z
dc.identifier.uri
https://refubium.fu-berlin.de/handle/fub188/24455
dc.identifier.uri
http://dx.doi.org/10.17169/refubium-2226
dc.description.abstract
Mixed adenoneuroendocrine carcinomas of the gastrointestinal tract are until today poorly understood and thus very challenging for interdisciplinary therapy. We herewith report the first case series of patients with a primary mixed adenoneuroendocrine carcinoma of the rectum. Both cases were initially diagnosed as adenocarcinoma and only secondarily with mixed adenoneuroendocrine carcinoma and had a poor outcome due to a rapid tumor progression and resistance to chemotherapy. A 65-year-old female presented with local tumor recurrence and hepatopulmonary metastasis 1 year after primary surgery for adenocarcinoma of the rectum and consecutive radiochemotherapy regimen. Fluorouracil (5-FU) was followed by bevacizumab- and capecitabine-based chemotherapy but had to be discontinued due to side effects and progressive disease. Progressive local pain syndrome accompanied by recurrent bleeding episodes led to a local tumor-debulking operation. Afterward, mixed adenoneuroendocrine carcinoma as the underlying diagnosis in the final histopathological examination was detected. The patient died 3 months after the operation in the context of a fulminant tumor progress. A 63-year-old male patient underwent neoadjuvant radiochemotherapy and laparoscopic rectum resection. After 5 months, postoperative oxaliplatin/capecitabine-based adjuvant chemotherapy was switched to carboplatin/etopsid due to a progressive polyneuropathy and biopsy-proven pulmonary metastasis. The patient then had to be switched to local radiation of cerebral metastases and Topotecan due to cerebral bleeding episodes but died 18 months after the initial diagnosis. In conclusion of our case series, mixed adenoneuroendocrine carcinomas of the rectum should be considered as a rare but aggressive tumor entity. An early and detailed histopathological diagnosis is required in order to establish an individual interdisciplinary treatment concept.
en
dc.rights.uri
https://creativecommons.org/licenses/by-nc/4.0/
dc.subject
Mixed adenoneuroendocrine carcinoma
en
dc.subject.ddc
600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit
dc.title
Two patients with rare mixed adenoneuroendocrine carcinomas of the rectum
dc.type
Wissenschaftlicher Artikel
dcterms.bibliographicCitation.doi
10.1177/2050313X18758816
dcterms.bibliographicCitation.journaltitle
SAGE Open Medical Case Reports
dcterms.bibliographicCitation.originalpublishername
SAGE Publishing
dcterms.bibliographicCitation.pagestart
1
dcterms.bibliographicCitation.pageend
6
dcterms.bibliographicCitation.volume
6
refubium.affiliation
Charité - Universitätsmedizin Berlin
refubium.resourceType.isindependentpub
no
dcterms.accessRights.openaire
open access
dcterms.bibliographicCitation.pmid
29568525
dcterms.isPartOf.issn
2050-313X