dc.contributor.author
Balz, Johanna
dc.contributor.author
Romero, Yadira Roa
dc.contributor.author
Keil, Julian
dc.contributor.author
Schubert, Florian
dc.contributor.author
Ittermann, Bernd
dc.contributor.author
Mekle, Ralf
dc.contributor.author
Montag, Christiane
dc.contributor.author
Gallinat, Jürgen
dc.contributor.author
Senkowski, Daniel
dc.date.accessioned
2019-04-15T13:56:11Z
dc.date.available
2019-04-15T13:56:11Z
dc.identifier.uri
https://refubium.fu-berlin.de/handle/fub188/24419
dc.identifier.uri
http://dx.doi.org/10.17169/refubium-2191
dc.description.abstract
Clinical studies suggest aberrant neurotransmitter concentrations in the brains of patients with schizophrenia (SCZ). Numerous studies have indicated deviant glutamate concentrations in SCZ, although the findings are inconsistent. Moreover, alterations in glutamate concentrations could be linked to personality traits in SCZ. Here, we examined the relationships between personality dimensions and glutamate concentrations in a voxel encompassing the occipital cortex (OCC) and another voxel encompassing the left superior temporal sulcus (STS). We used proton magnetic resonance spectroscopy to examine glutamate concentrations in the OCC and the STS in 19 SCZ and 21 non-psychiatric healthy control (HC) participants. Personality dimensions neuroticism, extraversion, openness, agreeableness and conscientiousness were assessed using the NEO-FFI questionnaire. SCZ compared to HC showed higher glutamate concentrations in the STS, reduced extraversion scores, and enhanced neuroticism scores. No group differences were observed for the other personality traits and for glutamate concentrations in the OCC. For the SCZ group, glutamate concentrations in STS were negatively correlated with the neuroticism scores [r = –0.537, p = 0.018] but this was not found in HC [r(19) = 0.011, p = 0.962]. No other significant correlations were found. Our study showed an inverse relationship between glutamate concentrations in the STS and neuroticism scores in SCZ. Elevated glutamate in the STS might serve as a compensatory mechanism that enables patients with enhanced concentrations to control and prevent the expression of neuroticism.
en
dc.rights.uri
https://creativecommons.org/licenses/by/4.0/
dc.subject
schizophrenia
en
dc.subject
magnetic resonance spectroscopy
en
dc.subject
superior temporal sulcus
en
dc.subject.ddc
600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit
dc.title
Glutamate Concentration in the Superior Temporal Sulcus Relates to Neuroticism in Schizophrenia
dc.type
Wissenschaftlicher Artikel
dcterms.bibliographicCitation.articlenumber
578
dcterms.bibliographicCitation.doi
10.3389/fpsyg.2018.00578
dcterms.bibliographicCitation.journaltitle
Frontiers in Psychology
dcterms.bibliographicCitation.originalpublishername
Frontiers Media S.A.
dcterms.bibliographicCitation.volume
9
refubium.affiliation
Charité - Universitätsmedizin Berlin
refubium.resourceType.isindependentpub
no
dcterms.accessRights.openaire
open access
dcterms.bibliographicCitation.pmid
29867621
dcterms.isPartOf.issn
1664-1078