dc.contributor.author
Folkerts, Jelle
dc.contributor.author
Stadhouders, Ralph
dc.contributor.author
Redegeld, Frank A.
dc.contributor.author
Tam, See-Ying
dc.contributor.author
Hendriks, Rudi W.
dc.contributor.author
Galli, Stephen J.
dc.contributor.author
Maurer, Marcus
dc.date.accessioned
2019-04-15T07:27:49Z
dc.date.available
2019-04-15T07:27:49Z
dc.identifier.uri
https://refubium.fu-berlin.de/handle/fub188/24410
dc.identifier.uri
http://dx.doi.org/10.17169/refubium-2182
dc.description.abstract
Many mast cell-associated diseases, including allergies and asthma, have seen a strong increase in prevalence during the past decades, especially in Western(ized) countries. It has been suggested that a Western diet may contribute to the prevalence and manifestation of allergies and asthma through reduced intake of dietary fiber and the subsequent production of their metabolites. Indeed, dietary fiber and its metabolites have been shown to positively influence the development of immune disorders via changes in microbiota composition and the regulation of B-and T-cell activation. However, the effects of these dietary components on the activation of mast cells, key effector cells of the inflammatory response in allergies and asthma, remain poorly characterized. Due to their location in the gut and vascularized tissues, mast cells are exposed to high concentrations of dietary fiber and/or its metabolites. Here, we provide a focused overview of current findings regarding the direct effects of dietary fiber and its various metabolites on the regulation of mast cell activity and the pathophysiology of mast cell-associated diseases.
en
dc.rights.uri
https://creativecommons.org/licenses/by/4.0/
dc.subject
dietary fiber
en
dc.subject
short-chain fatty acids
en
dc.subject.ddc
600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit
dc.title
Effect of dietary fiber and metabolites on mast cell activation and mast cell-associated diseases
dc.type
Wissenschaftlicher Artikel
dcterms.bibliographicCitation.articlenumber
1067
dcterms.bibliographicCitation.doi
10.3389/fimmu.2018.01067
dcterms.bibliographicCitation.journaltitle
Frontiers in Immunology
dcterms.bibliographicCitation.originalpublishername
Frontiers Media S.A.
dcterms.bibliographicCitation.volume
9
refubium.affiliation
Charité - Universitätsmedizin Berlin
refubium.resourceType.isindependentpub
no
dcterms.accessRights.openaire
open access
dcterms.bibliographicCitation.pmid
29910798
dcterms.isPartOf.issn
1664-3224