dc.contributor.author
Hoppe, Pia-Alice
dc.contributor.author
Hanitsch, Leif G.
dc.contributor.author
Leistner, Rasmus
dc.contributor.author
Niebank, Michaela
dc.contributor.author
Bührer, Christoph
dc.contributor.author
Bernuth, Horst von
dc.contributor.author
Krüger, Renate
dc.date.accessioned
2019-04-12T13:32:50Z
dc.date.available
2019-04-12T13:32:50Z
dc.identifier.uri
https://refubium.fu-berlin.de/handle/fub188/24390
dc.identifier.uri
http://dx.doi.org/10.17169/refubium-2162
dc.description.abstract
BACKGROUND: Colonisation with Panton-Valentine Leukocidin expressing strains of Staphylococcus aureus (PVL + SA) is characterised by recurrent skin and soft tissue infections. While periorbital and orbital infections are common in children and frequently caused by S. aureus the role of PVL + SA in recurrent eye infections has not been studied. This study aimed to detect and report frequency and recurrence of periorbital or orbital infections as additional symptoms of PVL + SA colonisation in children.
METHODS: We conducted a retrospective cohort study of pediatric patients who were treated for PVL + SA skin and soft tissue infection in our in- and outpatient clinics in Berlin, Germany from January 2012 to January 2017. We identified cases with periorbital or orbital infections in the year prior to the first PVL + SA evidence. In these cases, we conducted follow-up interviews by phone to determine recurrence of symptoms after the completion of decolonisation procedures.
RESULTS: Fifty pediatric patients (age range: one week to 17 years) were evaluated and treated for PVL + SA infections in the reported time period. 19 patients (38%) reported periorbital infection or conjunctivitis, with recurrent hordeola as the most frequent finding (n = 9; 18%). Reappearance of hordeola (n = 5) was associated with recurrence of skin and soft tissue infections and/or de novo detection of PVL + SA. No further hordeola or other eye infections occurred after successful decolonisation.
CONCLUSION: Our findings suggest a frequent involvement of periorbital skin in children with PVL + SA infections. Pediatric patients with recurrent periorbital infections might benefit from PVL + SA screening and consecutive decolonisation procedures.
en
dc.rights.uri
https://creativecommons.org/licenses/by/4.0/
dc.subject
Panton-Valentine Leucocidin (PVL)
en
dc.subject
Staphylococcus aureus
en
dc.subject
Eye infection
en
dc.subject.ddc
600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit
dc.title
Periorbital infections and conjunctivitis due to Panton-Valentine Leukocidin (PVL) positive Staphylococcus aureus in children
dc.type
Wissenschaftlicher Artikel
dcterms.bibliographicCitation.articlenumber
371
dcterms.bibliographicCitation.doi
10.1186/s12879-018-3281-8
dcterms.bibliographicCitation.journaltitle
BMC Infectious Diseases
dcterms.bibliographicCitation.originalpublishername
BMC
dcterms.bibliographicCitation.volume
18
refubium.affiliation
Charité - Universitätsmedizin Berlin
refubium.resourceType.isindependentpub
no
dcterms.accessRights.openaire
open access
dcterms.bibliographicCitation.pmid
30081842
dcterms.isPartOf.issn
1471-2334