dc.contributor.author
Russow, Gabriele
dc.contributor.author
Jahn, Denise
dc.contributor.author
Appelt, Jessika
dc.contributor.author
Märdian, Sven
dc.contributor.author
Tsitsilonis, Serafeim
dc.contributor.author
Keller, Johannes
dc.date.accessioned
2019-03-26T14:37:41Z
dc.date.available
2019-03-26T14:37:41Z
dc.identifier.uri
https://refubium.fu-berlin.de/handle/fub188/24195
dc.identifier.uri
http://dx.doi.org/10.17169/refubium-1967
dc.description.abstract
Osteoporosis represents the most common bone disease worldwide and results in a significantly increased fracture risk. Extrinsic and intrinsic factors implicated in the development of osteoporosis are also associated with delayed fracture healing and impaired bone regeneration. Based on a steadily increasing life expectancy in modern societies, the global implications of osteoporosis and impaired bone healing are substantial. Research in the last decades has revealed several molecular pathways that stimulate bone formation and could be targeted to treat both osteoporosis and impaired fracture healing. The identification and development of therapeutic approaches modulating bone formation, rather than bone resorption, fulfils an essential clinical need, as treatment options for reversing bone loss and promoting bone regeneration are limited. This review focuses on currently available and future approaches that may have the potential to achieve these aims.
en
dc.rights.uri
https://creativecommons.org/licenses/by/4.0/
dc.subject
osteoporosis
en
dc.subject
anabolic therapy
en
dc.subject
bone regeneration
en
dc.subject
parathyroid hormone
en
dc.subject.ddc
600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit
dc.title
Anabolic Therapies in Osteoporosis and Bone Regeneration
dc.type
Wissenschaftlicher Artikel
dcterms.bibliographicCitation.articlenumber
83
dcterms.bibliographicCitation.doi
10.3390/ijms20010083
dcterms.bibliographicCitation.journaltitle
International Journal of Molecular Sciences
dcterms.bibliographicCitation.number
1
dcterms.bibliographicCitation.originalpublishername
MDPI AG
dcterms.bibliographicCitation.volume
20
refubium.affiliation
Charité - Universitätsmedizin Berlin
refubium.resourceType.isindependentpub
no
dcterms.accessRights.openaire
open access
dcterms.bibliographicCitation.pmid
30587780
dcterms.isPartOf.issn
1422-0067