dc.contributor.author
Stief, Jonas D.
dc.contributor.author
Haase, Moritz
dc.contributor.author
Lüdemann, Lutz
dc.contributor.author
Theilig, Dorothea
dc.contributor.author
Schmelzle, Moritz
dc.contributor.author
Hamm, Bernd
dc.contributor.author
Denecke, Timm
dc.contributor.author
Geisel, Dominik
dc.date.accessioned
2019-03-25T13:06:07Z
dc.date.available
2019-03-25T13:06:07Z
dc.identifier.uri
https://refubium.fu-berlin.de/handle/fub188/24182
dc.identifier.uri
http://dx.doi.org/10.17169/refubium-1955
dc.description.abstract
Noninvasive early detection of liver cirrhosis and fibrosis is essential for management and therapy. The aim was to investigated whether a combination of the functional parameter relative enhancement (RE) on Gadoxetic Acid magnetic resonance imaging (Gd-EOB-DTPA-enhanced MRI) and the fibrosis parameter T1ρ distinguishes cirrhosis and healthy liver. We analyzed patients with Gd-EOB-DTPA-enhanced MRI and T1ρ mapping. Signal intensity was measured before and after contrast; RE was calculated. T1ρ was measured with circular regions of interest (T1ρ-cROI). A quotient of RE and T1ρ-cROI was calculated: the fibrosis function quotient (FFQ). Cirrhosis was evaluated based on morphology and secondary changes. 213 datasets were included. The difference between cirrhotic and noncirrhotic liver was 51.11 ms vs. 47.56 ms for T1ρ-cROI (p < 0.001), 0.59 vs. 0.70 for RE (p < 0.001), and 89.53 vs. 70.83 for FFQ (p < 0.001). T1ρ-cROI correlated with RE, r = -0.14 (p < 0.05). RE had an AUC of 0.73. The largest AUC had the FFQ with 0.79. The best cutoff value was 48.34 ms for T1ρ-cROI, 0.70 for RE and 78.59 ms for FFQ. In conclusion T1ρ and RE can distinguish between cirrhotic and noncirrhotic liver. The FFQ, which is the combination of the two, improves diagnostic performance.
en
dc.rights.uri
https://creativecommons.org/licenses/by/4.0/
dc.subject
magnetic resonance imaging
en
dc.subject.ddc
600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit
dc.title
Combined morphological and functional liver MRI using spin-lattice relaxation in the rotating frame (T1 ρ) in conjunction with Gadoxetic Acid-enhanced MRI
dc.type
Wissenschaftlicher Artikel
dcterms.bibliographicCitation.articlenumber
2083
dcterms.bibliographicCitation.doi
10.1038/s41598-018-37689-y
dcterms.bibliographicCitation.journaltitle
Scientific Reports
dcterms.bibliographicCitation.originalpublishername
Nature Publishing Group
dcterms.bibliographicCitation.volume
9
refubium.affiliation
Charité - Universitätsmedizin Berlin
refubium.resourceType.isindependentpub
no
dcterms.accessRights.openaire
open access
dcterms.bibliographicCitation.pmid
30765741
dcterms.isPartOf.issn
2045-2322