dc.contributor.author
Borghardt, Jens Markus
dc.contributor.author
Kloft, Charlotte
dc.contributor.author
Sharma, Ashish
dc.date.accessioned
2018-10-05T09:58:08Z
dc.date.available
2018-10-05T09:58:08Z
dc.identifier.uri
https://refubium.fu-berlin.de/handle/fub188/23045
dc.identifier.uri
http://dx.doi.org/10.17169/refubium-843
dc.description.abstract
The inhalation route is frequently used to administer drugs for the management of respiratory diseases such as asthma or chronic obstructive pulmonary disease. Compared with other routes of administration, inhalation offers a number of advantages in the treatment of these diseases. For example, via inhalation, a drug is directly delivered to the target organ, conferring high pulmonary drug concentrations and low systemic drug concentrations. Therefore, drug inhalation is typically associated with high pulmonary efficacy and minimal systemic side effects. The lung, as a target, represents an organ with a complex structure and multiple pulmonary-specific pharmacokinetic processes, including (1) drug particle/droplet deposition; (2) pulmonary drug dissolution; (3) mucociliary and macrophage clearance; (4) absorption to lung tissue; (5) pulmonary tissue retention and tissue metabolism; and (6) absorptive drug clearance to the systemic perfusion. In this review, we describe these pharmacokinetic processes and explain how they may be influenced by drug-, formulation- and device-, and patient-related factors. Furthermore, we highlight the complex interplay between these processes and describe, using the examples of inhaled albuterol, fluticasone propionate, budesonide, and olodaterol, how various sequential or parallel pulmonary processes should be considered in order to comprehend the pulmonary fate of inhaled drugs.
en
dc.format.extent
12 S.
de
dc.rights.uri
https://creativecommons.org/licenses/by/4.0/
de
dc.subject
Inhaled Therapy
en
dc.subject
Respiratory Disease
en
dc.subject.ddc
600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit
de
dc.title
Inhaled Therapy in Respiratory Disease
de
dc.type
Wissenschaftlicher Artikel
de
dc.title.subtitle
The Complex Interplay of Pulmonary Kinetic Processes
de
dcterms.bibliographicCitation.articlenumber
2732017
dcterms.bibliographicCitation.doi
10.1155/2018/2732017
dcterms.bibliographicCitation.journaltitle
Canadian Respiratory Journal
dcterms.bibliographicCitation.volume
2018
dcterms.bibliographicCitation.url
https://doi.org/10.1155/2018/2732017
de
refubium.affiliation
Biologie, Chemie, Pharmazie
de
refubium.note.author
Der Artikel wurde in einer reinen Open-Access-Zeitschrift publiziert.
de
refubium.resourceType.isindependentpub
no
de
dcterms.accessRights.openaire
open access
dcterms.isPartOf.issn
1198-2241 (Print)
dcterms.isPartOf.issn
1916-7245 (Online)