dc.contributor.author
Bey, Katharina
dc.contributor.author
Lennertz, Leonhard
dc.contributor.author
Grützmann, Rosa
dc.contributor.author
Heinzel, Stephan
dc.contributor.author
Kaufmann, Christian
dc.contributor.author
Klawohn, Julia
dc.contributor.author
Riesel, Anja
dc.contributor.author
Meyhöfer, Inga
dc.contributor.author
Ettinger, Ulrich
dc.contributor.author
Kathmann, Norbert
dc.contributor.author
Wagner, Michael
dc.date.accessioned
2018-07-13T11:11:45Z
dc.date.available
2018-07-13T11:11:45Z
dc.identifier.uri
https://refubium.fu-berlin.de/handle/fub188/22463
dc.identifier.uri
http://dx.doi.org/10.17169/refubium-270
dc.description.abstract
Increasing evidence indicates that patients with obsessive-compulsive disorder (OCD) exhibit alterations in fronto-striatal circuitry. Performance deficits in the antisaccade task would support this model, but results from previous small-scale studies have been inconclusive as either increased error rates, prolonged antisaccade latencies, both or neither have been reported in OCD patients. In order to address this issue, we investigated antisaccade performance in a large sample of OCD patients (n = 169) and matched control subjects (n = 183). As impaired antisaccade performance constitutes a potential endophenotype of OCD, unaffected first-degree relatives of OCD patients (n = 100) were assessed, as well. Furthermore, we conducted a quantitative meta-analysis to integrate our data with previous findings. In the empirical study, OCD patients exhibited significantly increased antisaccade latencies, intra-subject variability (ISV) of antisaccade latencies, and antisaccade error rates. The latter effect was driven by errors with express latency (80–130 ms), as patients did not differ significantly from controls with regards to regular errors (>130 ms). Notably, unaffected relatives of OCD patients showed elevated antisaccade express error rates and increased ISV of antisaccade latencies, as well. Antisaccade performance was not associated with state anxiety within groups. Among relatives, however, we observed a significant correlation between antisaccade error rate and harm avoidance. Medication status of OCD patients, symptom severity, depressive comorbidity, comorbid anxiety disorders and OCD symptom dimensions did not significantly affect antisaccade performance. Meta-analysis of 10 previous and the present empirical study yielded a medium-sized effect (SMD = 0.48, p < 0.001) for higher error rates in OCD patients, while the effect for latencies did not reach significance owing to strong heterogeneity (SMD = 0.51, p = 0.069). Our results support the assumption of impaired antisaccade performance in OCD, although effects sizes were only moderately large. Furthermore, we provide the first evidence that increased antisaccade express error rates and ISV of antisaccade latencies may constitute endophenotypes of OCD. Findings regarding these more detailed antisaccade parameters point to potentially underlying mechanisms, such as early pre-stimulus inhibition of the superior colliculus.
en
dc.format.extent
15 Seiten
de
dc.rights.uri
https://creativecommons.org/licenses/by/4.0/
de
dc.subject
obsessive-compulsive disorder
en
dc.subject
meta-analysis
en
dc.subject
eye-tracking
en
dc.subject.ddc
600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::616 Krankheiten
de
dc.title
Impaired Antisaccades in Obsessive-Compulsive Disorder: Evidence From Meta-Analysis and a Large Empirical Study
de
dc.type
Wissenschaftlicher Artikel
de
dcterms.bibliographicCitation.articlenumber
284
dcterms.bibliographicCitation.doi
10.3389/fpsyt.2018.00284
dcterms.bibliographicCitation.journaltitle
Frontiers in Psychiatry
dcterms.bibliographicCitation.volume
9
dcterms.bibliographicCitation.url
https://doi.org/10.3389/fpsyt.2018.00284
de
refubium.affiliation
Erziehungswissenschaft und Psychologie
de
refubium.affiliation.other
Klinische Psychologie und Psychotherapie
de
refubium.note.author
Der Artikel wurde in einer reinen Open-Access-Zeitschrift publiziert.
de
refubium.resourceType.isindependentpub
no
dcterms.accessRights.openaire
open access
dcterms.isPartOf.issn
1664-0640