dc.contributor.author
Skaradziska, Aneta
dc.contributor.author
Sliwka, Paulina
dc.contributor.author
Kuzminska-Bajor, Marta
dc.contributor.author
Friese, Anika
dc.contributor.author
Roschanski, Nicole
dc.contributor.author
Murugaiyan, Jayaseelan
dc.contributor.author
Roesler, Uwe H.
dc.date.accessioned
2018-06-08T11:10:10Z
dc.date.available
2017-05-08T09:49:32.090Z
dc.identifier.uri
https://refubium.fu-berlin.de/handle/fub188/21751
dc.identifier.uri
http://dx.doi.org/10.17169/refubium-25039
dc.description.abstract
Extended-spectrum β-lactamases (ESBLs) and AmpC β-lactamases are plasmid (but
also chromosomally) encoded enzymes found in Enterobacteriaceae, determining
resistance to a variety of important antibiotics including penicillins,
cephalosporins, and monobactams. In recent decades, the prevalence of ESBL
/AmpC-producing bacteria has increased rapidly across the world. Here, we
evaluate the potential use of bacteriophages in terms of a reduction of
antibiotic-resistant bacteria in healthy animals. The aim of our studies was
to isolate bacteriophages capable of destroying ESBL/AmpC-producing
Escherichia coli isolated from livestock habitats. The efficacy of isolated
phages against ESBL/AmpC E. coli strains varies, but creation of a phage
cocktail with broad activity spectrum is possible. This may indicate that the
role of phages may not be limited to phage therapy, but bacterial viruses may
also be applied against spread of bacteria with antibiotic resistance genes in
the environment. We also addressed the hypothesis, that phages, effective for
therapeutic purposes may be isolated from distant places and even from
different environments other than the actual location of the targeted
bacteria. This may be beneficial for practical purposes, as the construction
of effective phage preparations does not require access to disease outbreaks.
en
dc.rights.uri
http://creativecommons.org/licenses/by/4.0/
dc.subject
bacteriophages
dc.subject
antibiotic resistance
dc.subject
antibiotic resistance genes
dc.subject
ESBL/AmpC resistant E. coli
dc.subject.ddc
600 Technik, Medizin, angewandte Wissenschaften::630 Landwirtschaft
dc.title
The efficacy of isolated bacteriophages from pig farms against ESBL/AmpC-
producing Escherichia coli from pig and Turkey farms
dc.type
Wissenschaftlicher Artikel
dcterms.bibliographicCitation
Frontiers in Microbiology. - 8 (2017), Artikel Nr. 530
dcterms.bibliographicCitation.doi
10.3389/fmicb.2017.00530
dcterms.bibliographicCitation.url
http://doi.org/10.3389/fmicb.2017.00530
refubium.affiliation
Veterinärmedizin
de
refubium.mycore.fudocsId
FUDOCS_document_000000026966
refubium.note.author
Der Artikel wurde in einer reinen Open-Access-Zeitschrift publiziert.
refubium.resourceType.isindependentpub
no
refubium.mycore.derivateId
FUDOCS_derivate_000000008150
dcterms.accessRights.openaire
open access