dc.contributor.author
Nunes-Souza, Valeria
dc.contributor.author
Alenina, Natalia
dc.contributor.author
Qadri, Fatimunnisa
dc.contributor.author
Penninger, Josef M.
dc.contributor.author
Santos, Robson Augusto S.
dc.contributor.author
Bader, Michael
dc.contributor.author
Rabelo, Luiza A.
dc.date.accessioned
2018-06-08T11:08:50Z
dc.date.available
2017-02-20T10:21:24.711Z
dc.identifier.uri
https://refubium.fu-berlin.de/handle/fub188/21694
dc.identifier.uri
http://dx.doi.org/10.17169/refubium-24982
dc.description.abstract
Background and Aims. Angiotensin converting enzyme 2 (ACE2) is an important
component of the renin-angiotensin system. Since angiotensin peptides have
been shown to be involved in hepatic steatosis, we aimed to evaluate the
hepatic lipid profile in ACE2-deficient (ACE2-/y) mice. Methods. Male C57BL/6
and ACE2-/y mice were analyzed at the age of 3 and 6 months for alterations in
the lipid profiles of plasma, faeces, and liver and for hepatic steatosis.
Results. ACE2-/y mice showed lower body weight and white adipose tissue at all
ages investigated. Moreover, these mice had lower levels of cholesterol,
triglycerides, and nonesterified fatty acids in plasma. Strikingly, ACE2-/y
mice showed high deposition of lipids in the liver. Expression of CD36, a
protein involved in the uptake of triglycerides in liver, was increased in
ACE2-/y mice. Concurrently, these mice exhibited an increase in hepatic
oxidative stress, evidenced by increased lipid peroxidation and expression of
uncoupling protein 2, and downregulation of sirtuin 1. ACE2-/y mice also
showed impairments in glucose metabolism and insulin signaling in the liver.
Conclusions. Deletion of ACE2-/y causes CD36/sirtuin 1 axis impairment and
thereby interferes with lipid homeostasis, leading to lipodystrophy and
steatosis.
de
dc.rights.uri
http://creativecommons.org/licenses/by/4.0/
dc.subject.ddc
600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit
dc.title
CD36/Sirtuin 1 Axis Impairment Contributes to Hepatic Steatosis in
ACE2-Deficient Mice
dc.type
Wissenschaftlicher Artikel
dcterms.bibliographicCitation
Oxidative Medicine and Cellular Longevity. - 2016 (2016), Artikel Nr. 6487509
dcterms.bibliographicCitation.doi
10.1155/2016/6487509
dcterms.bibliographicCitation.url
http://dx.doi.org/10.1155/2016/6487509
refubium.affiliation
Charité - Universitätsmedizin Berlin
de
refubium.mycore.fudocsId
FUDOCS_document_000000026372
refubium.note.author
Der Artikel wurde in einer reinen Open-Access-Zeitschrift publiziert.
refubium.resourceType.isindependentpub
no
refubium.mycore.derivateId
FUDOCS_derivate_000000007715
dcterms.accessRights.openaire
open access