dc.contributor.author
Schueler, Rita
dc.contributor.author
Osterhoff, Martin A.
dc.contributor.author
Frahnow, Turid
dc.contributor.author
Moehlig, Matthias
dc.contributor.author
Spranger, Joachim
dc.contributor.author
Stefanovski, Darko
dc.contributor.author
Bergman, Richard
dc.contributor.author
Xu, Li
dc.contributor.author
Seltmann, Anne-Cathrin
dc.contributor.author
Kabisch, Stefan
dc.contributor.author
Hornemann, Silke
dc.contributor.author
Kruse, Michael
dc.contributor.author
Pfeiffer, Andreas F. H.
dc.date.accessioned
2018-06-08T11:06:02Z
dc.date.available
2017-09-29T10:27:07.778Z
dc.identifier.uri
https://refubium.fu-berlin.de/handle/fub188/21603
dc.identifier.uri
http://dx.doi.org/10.17169/refubium-24892
dc.description.abstract
The frequent ACE insertion/deletion polymorphism (I/D) is, albeit
inconsistently, associated with impaired glucose tolerance and insulin
resistance. We recently observed an enhanced upregulation of ACE by elevated
fat intake in GG-carriers of the I/D-surrogate rs4343 variant and therefore
investigated its potential nutrigenetic role in glucose metabolism. In this
nutritional intervention study 46 healthy and non-obese twin pairs consumed
recommended low fat diets for 6 weeks before they received a 6-week high fat
(HF) diet under isocaloric conditions. Intravenous glucose tolerance tests
were performed before and after 1 and 6 weeks of HF diet. While glucose
tolerance did not differ between genotypes at baseline it significantly
declined in GG-carriers after 6 weeks HF diet (p = 0.001) with higher 2 h
glucose and insulin concentrations compared to AA/AG-carriers (p = 0.003 and p
= 0.042). Furthermore, the gene-diet interaction was confirmed in the cross-
sectional Metabolic Syndrome Berlin Potsdam study (p = 0.012), with the GG-
genotypes being significantly associated with prevalent type 2 diabetes for
participants with high dietary fat intake ≥37% (GG vs. AA/AG, OR 2.36
[1.02–5.49], p = 0.045). In conclusion, the association between the rs4343
variant and glucose tolerance is modulated by dietary fat intake. The ACE
rs4343 variant is a novel nutrient-sensitive type 2 diabetes risk marker
potentially applicable for nutrigenetic dietary counseling.
en
dc.rights.uri
http://creativecommons.org/licenses/by/4.0/
dc.subject
Clinical trials
dc.subject
Genetic interaction
dc.subject.ddc
600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit
dc.title
Dietary Fat Intake Modulates Effects of a Frequent ACE Gene Variant on Glucose
Tolerance with association to Type 2 Diabetes
dc.type
Wissenschaftlicher Artikel
dcterms.bibliographicCitation
Scientific Reports. - 7 (2017), Artikel Nr. 9234
dcterms.bibliographicCitation.doi
10.1038/s41598-017-08300-7
dcterms.bibliographicCitation.url
http://www.nature.com/articles/s41598-017-08300-7
refubium.affiliation
Charité - Universitätsmedizin Berlin
de
refubium.mycore.fudocsId
FUDOCS_document_000000028059
refubium.note.author
Der Artikel wurde in einer reinen Open-Access-Zeitschrift publiziert.
refubium.resourceType.isindependentpub
no
refubium.mycore.derivateId
FUDOCS_derivate_000000008818
dcterms.accessRights.openaire
open access