dc.contributor.author
Mika , Franziska
dc.contributor.author
Hengge, Regine
dc.date.accessioned
2018-06-08T11:00:56Z
dc.date.available
2018-01-25T11:43:15.966Z
dc.identifier.uri
https://refubium.fu-berlin.de/handle/fub188/21470
dc.identifier.uri
http://dx.doi.org/10.17169/refubium-24762
dc.description.abstract
Biofilm formation in Escherichia coli and other enteric bacteria involves the
inverse regulation of the synthesis of flagella and biofilm matrix components
such as amyloid curli fibres, cellulose, colanic acid and
poly-N-acetylglucosamine (PGA). Physiologically, these processes reflect the
transition from growth to stationary phase. At the molecular level, they are
tightly controlled by various sigma factors competing for RNA polymerase, a
series of transcription factors acting in hierarchical regulatory cascades and
several nucleotide messengers, including cyclic-di-GMP. In addition, a
surprisingly large number of small regulatory RNAs (sRNAs) have been shown to
directly or indirectly modulate motility and/or biofilm formation. This review
aims at giving an overview of these sRNA regulators and their impact in
biofilm formation in E. coli and Salmonella. Special emphasis will be put on
sRNAs, that have known targets such as the mRNAs of the flagellar master
regulator FlhDC, the stationary phase sigma factor σS (RpoS) and the key
biofilm regulator CsgD that have recently been shown to act as major hubs for
regulation by multiple sRNAs. View Full-Text
en
dc.rights.uri
http://creativecommons.org/licenses/by-nc-sa/3.0/
dc.subject
biofilm matrix
dc.subject.ddc
500 Naturwissenschaften und Mathematik::570 Biowissenschaften; Biologie
dc.title
Small Regulatory RNAs in the Control of Motility and Biofilm Formation in E.
coli and Salmonella
dc.type
Wissenschaftlicher Artikel
dcterms.bibliographicCitation
Int. J. Mol. Sci. - 14 (2013), 3, S. 4560-4579
dcterms.bibliographicCitation.doi
10.3390/ijms14034560
dcterms.bibliographicCitation.url
http://www.mdpi.com/1422-0067/14/3/4560
refubium.affiliation
Biologie, Chemie, Pharmazie
de
refubium.mycore.fudocsId
FUDOCS_document_000000028873
refubium.note.author
Der Artikel wurde in einer reinen Open-Access-Zeitschrift publiziert.
refubium.resourceType.isindependentpub
no
refubium.mycore.derivateId
FUDOCS_derivate_000000009367
dcterms.accessRights.openaire
open access