dc.contributor.author
Witt, S. H.
dc.contributor.author
Streit, F.
dc.contributor.author
Jungkunz, M.
dc.contributor.author
Frank, J.
dc.contributor.author
Awasthi, S.
dc.contributor.author
Reinbold, C. S.
dc.contributor.author
Treutlein, J.
dc.contributor.author
Degenhardt, F.
dc.contributor.author
Forstner, A. J. [u. v. m.]
dc.date.accessioned
2018-06-08T10:59:32Z
dc.date.available
2017-07-14T11:22:54.310Z
dc.identifier.uri
https://refubium.fu-berlin.de/handle/fub188/21444
dc.identifier.uri
http://dx.doi.org/10.17169/refubium-24737
dc.description.abstract
Borderline personality disorder (BOR) is determined by environmental and
genetic factors, and characterized by affective instability and impulsivity,
diagnostic symptoms also observed in manic phases of bipolar disorder (BIP).
Up to 20% of BIP patients show comorbidity with BOR. This report describes the
first case–control genome-wide association study (GWAS) of BOR, performed in
one of the largest BOR patient samples worldwide. The focus of our analysis
was (i) to detect genes and gene sets involved in BOR and (ii) to investigate
the genetic overlap with BIP. As there is considerable genetic overlap between
BIP, major depression (MDD) and schizophrenia (SCZ) and a high comorbidity of
BOR and MDD, we also analyzed the genetic overlap of BOR with SCZ and MDD.
GWAS, gene-based tests and gene-set analyses were performed in 998 BOR
patients and 1545 controls. Linkage disequilibrium score regression was used
to detect the genetic overlap between BOR and these disorders. Single marker
analysis revealed no significant association after correction for multiple
testing. Gene-based analysis yielded two significant genes: DPYD (P=4.42 ×
10−7) and PKP4 (P=8.67 × 10−7); and gene-set analysis yielded a significant
finding for exocytosis (GO:0006887, PFDR=0.019; FDR, false discovery rate).
Prior studies have implicated DPYD, PKP4 and exocytosis in BIP and SCZ. The
most notable finding of the present study was the genetic overlap of BOR with
BIP (rg=0.28 [P=2.99 × 10−3]), SCZ (rg=0.34 [P=4.37 × 10−5]) and MDD (rg=0.57
[P=1.04 × 10−3]). We believe our study is the first to demonstrate that BOR
overlaps with BIP, MDD and SCZ on the genetic level. Whether this is confined
to transdiagnostic clinical symptoms should be examined in future studies.
en
dc.rights.uri
http://creativecommons.org/licenses/by/4.0/
dc.subject.ddc
600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit
dc.title
Genome-wide association study of borderline personality disorder reveals
genetic overlap with bipolar disorder, major depression and schizophrenia
dc.type
Wissenschaftlicher Artikel
dcterms.bibliographicCitation
Translational Psychiatry. - 7 (2017), Artikel Nr. e1155
dcterms.bibliographicCitation.doi
10.1038/tp.2017.115
dcterms.bibliographicCitation.url
http://www.nature.com/tp/journal/v7/n6/full/tp2017115a.html
refubium.affiliation
Charité - Universitätsmedizin Berlin
de
refubium.mycore.fudocsId
FUDOCS_document_000000027368
refubium.note.author
Der Artikel wurde in einer reinen Open-Access-Zeitschrift publiziert.
refubium.resourceType.isindependentpub
no
refubium.mycore.derivateId
FUDOCS_derivate_000000008483
dcterms.accessRights.openaire
open access