dc.contributor.author
Weiner, Juliane
dc.contributor.author
Kranz, Mathias
dc.contributor.author
Klöting, Nora
dc.contributor.author
Kunath, Anne
dc.contributor.author
Steinhoff, Karen
dc.contributor.author
Rijntjes, Eddy
dc.contributor.author
Köhrle, Josef
dc.contributor.author
Zeisig, Vilia
dc.contributor.author
Hankir, Mohammed [u.v.m.]
dc.date.accessioned
2018-06-08T10:55:25Z
dc.date.available
2017-02-01T12:25:11.813Z
dc.identifier.uri
https://refubium.fu-berlin.de/handle/fub188/21341
dc.identifier.uri
http://dx.doi.org/10.17169/refubium-24636
dc.description.abstract
The present study aimed to determine the effect of thyroid hormone dysfunction
on brown adipose tissue activity and white adipose tissue browning in mice.
Twenty randomized female C57BL/6NTac mice per treatment group housed at room
temperature were rendered hypothyroid or hyperthyroid. In-vivo small animal
18F-FDG PET/MRI was performed to determine the effects of hypo- and
hyperthyroidism on BAT mass and BAT activity. Ex-vivo14C-acetate loading assay
and assessment of thermogenic gene and protein expression permitted analysis
of oxidative and thermogenic capacities of WAT and BAT of eu-, hyper and
hypothyroid mice. 18F-FDG PET/MRI revealed a lack of brown adipose tissue
activity in hypothyroid mice, whereas hyperthyroid mice displayed increased
BAT mass alongside enhanced 18F-FDG uptake. In white adipose tissue of both,
hyper- and hypothyroid mice, we found a significant induction of thermogenic
genes together with multilocular adipocytes expressing UCP1. Taken together,
these results suggest that both the hyperthyroid and hypothyroid state
stimulate WAT thermogenesis most likely as a consequence of enhanced
adrenergic signaling or compensation for impaired BAT function, respectively.
en
dc.rights.uri
http://creativecommons.org/licenses/by/4.0/
dc.subject
Thyroid diseases
dc.subject.ddc
600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit
dc.title
Thyroid hormone status defines brown adipose tissue activity and browning of
white adipose tissues in mice
dc.type
Wissenschaftlicher Artikel
dcterms.bibliographicCitation
Scientific Reports. - 6 (2016), Artikel Nr. 38124
dcterms.bibliographicCitation.doi
10.1038/srep38124
dcterms.bibliographicCitation.url
http://www.nature.com/articles/srep38124
refubium.affiliation
Charité - Universitätsmedizin Berlin
de
refubium.mycore.fudocsId
FUDOCS_document_000000026238
refubium.note.author
Der Artikel wurde in einer reinen Open-Access-Zeitschrift publiziert.
refubium.resourceType.isindependentpub
no
refubium.mycore.derivateId
FUDOCS_derivate_000000007609
dcterms.accessRights.openaire
open access