dc.contributor.author
Abuelizz, Hatem A.
dc.contributor.author
Al-Salahi, Rashad
dc.contributor.author
Al-Asri, Jamil
dc.contributor.author
Mortier, Jeremie
dc.contributor.author
Marzouk, Mohamed
dc.contributor.author
Ezzeldin, Essam
dc.contributor.author
Ali, Azza A.
dc.contributor.author
Khalil, Mona G.
dc.contributor.author
Wolber, Gerhard
dc.contributor.author
Ghabbour, Hazem A.
dc.contributor.author
Almehizia, Abdulrahman A.
dc.contributor.author
Jaleel, Gehad A. Abdel
dc.date.accessioned
2018-06-08T10:54:44Z
dc.date.available
2017-11-16T11:36:59.378Z
dc.identifier.uri
https://refubium.fu-berlin.de/handle/fub188/21311
dc.identifier.uri
http://dx.doi.org/10.17169/refubium-24606
dc.description.abstract
The main objective of this work was to synthesize novel compounds with a
benzo[de][1,2,4]triazolo[5,1-a]isoquinoline scaffold by employing (dioxo-
benzo[de]isoquinolin-2-yl) thiourea as a building block. Molecular docking was
conducted in the COX-2 active site to predict the plausible binding mode and
rationalize the structure–activity relationship of the synthesized compounds.
The structures of the synthesized compounds were confirmed by HREI-MS, and NMR
spectra along with X-ray diffraction were collected for products 1 and 5.
Thereafter, anti-inflammatory effect of molecules 1–20 was evaluated in vivo
using carrageenan-induced paw edema method, revealing significant inhibition
potency in albino rats with an activity comparable to that of the standard
drugs indomethacin. Compounds 8, 9, 15 and 16 showed the highest anti-
inflammatory activity. However, thermal sensitivity-hot plat test, a
radiological examination and motor coordination assessment were performed to
test the activity against rheumatoid arthritis. The obtained results indicate
promising anti-arthritic activity for compounds 9 and 15 as significant
reduction of the serum level of interleukin-1β [IL-1β], cyclooxygenase-2
[COX-2] and prostaglandin E2 [PGE2] was observed in CFA rats.
en
dc.rights.uri
http://creativecommons.org/licenses/by/4.0/
dc.subject.ddc
500 Naturwissenschaften und Mathematik::540 Chemie
dc.title
Synthesis, crystallographic characterization, molecular docking and biological
activity of isoquinoline derivatives
dc.type
Wissenschaftlicher Artikel
dcterms.bibliographicCitation
Chemistry Central Journal. - 11 (2017), Artikel Nr. 103
dcterms.bibliographicCitation.doi
10.1186/s13065-017-0321-1
dcterms.bibliographicCitation.url
http://doi.org/10.1186/s13065-017-0321-1
refubium.affiliation
Biologie, Chemie, Pharmazie
de
refubium.mycore.fudocsId
FUDOCS_document_000000028488
refubium.note.author
Der Artikel wurde in einer reinen Open-Access-Zeitschrift publiziert.
refubium.resourceType.isindependentpub
no
refubium.mycore.derivateId
FUDOCS_derivate_000000009120
dcterms.accessRights.openaire
open access