Title:
Biodegradable Core–Multishell Nanocarriers
Subtitle:
Influence of Inner Shell Structure on the Encapsulation Behavior of
Dexamethasone and Tacrolimus
Author(s):
Unbehauen, Michael L.; Fleige, Emanuel; Paulus, Florian; Schemmer, Brigitta; Mecking, Stefan; More, Sam Dylan; Haag, Rainer
Year of publication:
2017
Available Date:
2017-10-12T10:10:22.254Z
Abstract:
We here present the synthesis and characterization of a set of biodegradable
core–multishell (CMS) nanocarriers. The CMS nanocarrier structure consists of
hyperbranched polyglycerol (hPG) as core material, a hydrophobic (12, 15, 18,
19, and 36 C-atoms) inner and a polyethylene glycol monomethyl ether (mPEG)
outer shell that were conjugated by ester bonds only to reduce the toxicity of
metabolites. The loading capacities (LC) of the drugs, dexamethasone and
tacrolimus, and the aggregate formation, phase transitions, and degradation
kinetics were determined. The intermediate inner shell length (C15) system had
the best overall performance with good LCs for both drugs as well as a
promising degradation and release kinetics, which are of interest for dermal
delivery
Keywords:
biodegradable CMS nanocarrier
drug delivery
dendritic polymers
dexamethasone
tacrolimus
DDC-Classification:
540 Chemie
Publication Type:
Wissenschaftlicher Artikel
Also published in:
Polymers. - 9 (2017), 8, Artkel Nr. 316
URL of the Original Publication:
DOI of the Original Publication:
Department/institution:
Biologie, Chemie, Pharmazie
Comments:
Der Artikel wurde in einer reinen Open-Access-Zeitschrift publiziert.
