dc.contributor.author
Preußner, Marco
dc.contributor.author
Heyd, Florian
dc.date.accessioned
2018-06-08T10:53:30Z
dc.date.available
2017-06-23T09:29:57.705Z
dc.identifier.uri
https://refubium.fu-berlin.de/handle/fub188/21284
dc.identifier.uri
http://dx.doi.org/10.17169/refubium-24579
dc.description.abstract
Many aspects of human physiology and behavior display rhythmicity with a
period of approximately 24 h. Rhythmic changes are controlled by an endogenous
time keeper, the circadian clock, and include sleep-wake cycles, physical and
mental performance capability, blood pressure, and body temperature.
Consequently, many diseases, such as metabolic, sleep, autoimmune and mental
disorders and cancer, are connected to the circadian rhythm. The development
of therapies that take circadian biology into account is thus a promising
strategy to improve treatments of diverse disorders, ranging from allergic
syndromes to cancer. Circadian alteration of body functions and behavior are,
at the molecular level, controlled and mediated by widespread changes in gene
expression that happen in anticipation of predictably changing requirements
during the day. At the core of the molecular clockwork is a well-studied
transcription-translation negative feedback loop. However, evidence is
emerging that additional post-transcriptional, RNA-based mechanisms are
required to maintain proper clock function. Here, we will discuss recent work
implicating regulated mRNA stability, translation and alternative splicing in
the control of the mammalian circadian clock, and its role in health and
disease.
en
dc.rights.uri
http://www.springer.com/gp/open-access/springer-open-choice
dc.subject
Circadian clock
dc.subject
Post-transcriptional regulation of gene expression
dc.subject
Chronomedicine
dc.subject
Alternative splicing mRNA stability Translation
dc.subject.ddc
500 Naturwissenschaften und Mathematik::570 Biowissenschaften; Biologie::572 Biochemie
dc.title
Post-transcriptional control of the mammalian circadian clock
dc.type
Wissenschaftlicher Artikel
dcterms.bibliographicCitation
Pflügers Archiv - European Journal of Physiology. - 468 (2016), 6, S. 983-991
dc.identifier.sepid
56097
dc.title.subtitle
implications for health and disease
dcterms.bibliographicCitation.doi
10.1007/s00424-016-1820-y
dcterms.bibliographicCitation.url
http://dx.doi.org/10.1007/s00424-016-1820-y
refubium.affiliation
Biologie, Chemie, Pharmazie
de
refubium.mycore.fudocsId
FUDOCS_document_000000027234
refubium.resourceType.isindependentpub
no
refubium.mycore.derivateId
FUDOCS_derivate_000000008358
dcterms.accessRights.openaire
open access
dcterms.isPartOf.issn
0031-6768