dc.contributor.author
Pett, J. Patrick
dc.contributor.author
Korencic, Anja
dc.contributor.author
Wesener, Felix
dc.contributor.author
Kramer, Achim
dc.contributor.author
Herzel, Hanspeter
dc.date.accessioned
2018-06-08T10:53:28Z
dc.date.available
2017-03-17T11:33:42.933Z
dc.identifier.uri
https://refubium.fu-berlin.de/handle/fub188/21283
dc.identifier.uri
http://dx.doi.org/10.17169/refubium-24578
dc.description.abstract
Mammals evolved an endogenous timing system to coordinate their physiology and
behaviour to the 24h period of the solar day. While it is well accepted that
circadian rhythms are generated by intracellular transcriptional feedback
loops, it is still debated which network motifs are necessary and sufficient
for generating self-sustained oscillations. Here, we systematically explore a
data-based circadian oscillator model with multiple negative and positive
feedback loops and identify a series of three subsequent inhibitions known as
“repressilator” as a core element of the mammalian circadian oscillator. The
central role of the repressilator motif is consistent with time-resolved ChIP-
seq experiments of circadian clock transcription factors and loss of
rhythmicity in core clock gene knockouts.
en
dc.rights.uri
http://creativecommons.org/licenses/by/4.0/
dc.subject.ddc
600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit
dc.title
Feedback Loops of the Mammalian Circadian Clock Constitute Repressilator
dc.type
Wissenschaftlicher Artikel
dcterms.bibliographicCitation
PLoS Comput Biol. - 12 (2016), 12, Artikel Nr. e1005266
dcterms.bibliographicCitation.doi
10.1371/journal.pcbi.1005266
dcterms.bibliographicCitation.url
http://dx.doi.org/10.1371/journal.pcbi.1005266
refubium.affiliation
Charité - Universitätsmedizin Berlin
de
refubium.mycore.fudocsId
FUDOCS_document_000000026658
refubium.note.author
Der Artikel wurde in einer reinen Open-Access-Zeitschrift publiziert.
refubium.resourceType.isindependentpub
no
refubium.mycore.derivateId
FUDOCS_derivate_000000007916
dcterms.accessRights.openaire
open access