dc.contributor.author
Decker, Sarah
dc.contributor.author
Rempis, Eva
dc.contributor.author
Schnack, Alexandra
dc.contributor.author
Braun, Vera
dc.contributor.author
Rubaihayo, John
dc.contributor.author
Busingye, Priscilla
dc.contributor.author
Tumwesigye, Nazarius Mbona
dc.contributor.author
Harms, Gundel
dc.contributor.author
Theuring, Stefanie
dc.date.accessioned
2018-06-08T10:51:48Z
dc.date.available
2017-07-31T07:04:14.533Z
dc.identifier.uri
https://refubium.fu-berlin.de/handle/fub188/21230
dc.identifier.uri
http://dx.doi.org/10.17169/refubium-24526
dc.description.abstract
Since 2012, the WHO recommends Option B+ for the prevention of mother-to-child
transmission of HIV. This approach entails the initiation of lifelong
antiretroviral therapy in all HIV-positive pregnant women, also implying
protection during breastfeeding for 12 months or longer. Research on long-term
adherence to Option B+ throughout breastfeeding is scarce to date. Therefore,
we conducted a prospective observational cohort study in Fort Portal, Western
Uganda, to assess adherence to Option B+ until 18 months postpartum. In 2013,
we recruited 67 HIV-positive, Option B+ enrolled women six weeks after giving
birth and scheduled them for follow-up study visits after six, twelve and 18
months. Two adherence measures, self-reported drug intake and amount of drug
refill visits, were combined to define adherence, and were assessed together
with feeding information at all study visits. At six months postpartum, 51% of
the enrolled women were considered to be adherent. Until twelve and 18 months
postpartum, adherence for the respective follow-up interval decreased to 19%
and 20.5% respectively. No woman was completely adherent until 18 months. At
the same time, 76.5% of the women breastfed for ≥12 months. Drug adherence was
associated with younger age (p<0.01), lower travel costs (p = 0.02), and lower
number of previous deliveries (p = 0.04). Long-term adherence to Option B+
seems to be challenging. Considering that in our cohort, prolonged
breastfeeding until ≥12 months was widely applied while postpartum adherence
until the end of breastfeeding was poor, a potential risk of postpartum
vertical transmission needs to be taken seriously into account for Option B+
implementation.
en
dc.format.extent
13 Seiten
dc.rights.uri
http://creativecommons.org/licenses/by/4.0/
dc.subject
HIV transmission
dc.subject
mother-to-child transmission
dc.subject
Western Uganda
dc.subject.ddc
600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::616 Krankheiten
dc.subject.ddc
900 Geschichte und Geografie::960 Geschichte Afrikas::967 Geschichte Zentralafrikas und vorgelagerter Inseln
dc.title
Prevention of mother-to-child transmission of HIV
dc.type
Wissenschaftlicher Artikel
dcterms.bibliographicCitation
PLoS ONE. - 12 (2017), 6, e0179448
dc.title.subtitle
Postpartum adherence to Option B+ until 18 months in Western Uganda
dcterms.bibliographicCitation.doi
10.1371/journal.pone.0179448
dcterms.bibliographicCitation.url
http://doi.org/10.1371/journal.pone.0179448
refubium.affiliation
Charité - Universitätsmedizin Berlin
de
refubium.mycore.fudocsId
FUDOCS_document_000000027474
refubium.note.author
Der Artikel wurde in einer Open-Access-Zeitschrift publiziert.
refubium.resourceType.isindependentpub
no
refubium.mycore.derivateId
FUDOCS_derivate_000000008583
dcterms.accessRights.openaire
open access
dcterms.isPartOf.issn
1932-6203