Background Fruits and vegetables are rich in compounds with proposed
antioxidant, anti-allergic and anti-inflammatory properties, which could
contribute to reduce the prevalence of asthma and allergic diseases. Objective
We investigated the association between asthma, and chronic rhino-sinusitis
(CRS) with intake of fruits and vegetables in European adults. Methods A
stratified random sample was drawn from the Global Allergy and Asthma Network
of Excellence (GA2LEN) screening survey, in which 55,000 adults aged 15–75
answered a questionnaire on respiratory symptoms. Asthma score (derived from
self-reported asthma symptoms) and CRS were the outcomes of interest. Dietary
intake of 22 subgroups of fruits and vegetables was ascertained using the
internationally validated GA2LEN Food Frequency Questionnaire. Adjusted
associations were examined with negative binomial and multiple regressions.
Simes procedure was used to control for multiple testing. Results A total of
3206 individuals had valid data on asthma and dietary exposures of interest.
22.8% reported having at least 1 asthma symptom (asthma score ≥1), whilst
19.5% had CRS. After adjustment for potential confounders, asthma score was
negatively associated with intake of dried fruits (β-coefficient −2.34; 95%
confidence interval [CI] −4.09, −0.59), whilst CRS was statistically
negatively associated with total intake of fruits (OR 0.73; 95% CI 0.55,
0.97). Conversely, a positive association was observed between asthma score
and alliums vegetables (adjusted β-coefficient 0.23; 95% CI 0.06, 0.40). None
of these associations remained statistically significant after controlling for
multiple testing. Conclusion and clinical relevance There was no consistent
evidence for an association of asthma or CRS with fruit and vegetable intake
in this representative sample of European adults.
600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit
Is fruit and vegetable intake associated with asthma or chronic rhino-
sinusitis in European adults?
Clinical and Translational Allergy. - 7 (2017), Artikel Nr. 3
Results from the Global Allergy and Asthma Network of Excellence (GA2LEN)
Charité - Universitätsmedizin Berlin