dc.contributor.author
Kheimar, Ahmed
dc.contributor.author
Previdelli, Renato L.
dc.contributor.author
Wight, Darren J.
dc.contributor.author
Kaufer, Benedikt B.
dc.date.accessioned
2018-06-08T10:48:19Z
dc.date.available
2017-09-08T10:48:18.297Z
dc.identifier.uri
https://refubium.fu-berlin.de/handle/fub188/21104
dc.identifier.uri
http://dx.doi.org/10.17169/refubium-24401
dc.description.abstract
Telomeres protect the ends of vertebrate chromosomes from deterioration and
consist of tandem nucleotide repeats (TTAGGG)n that are associated with a
number of proteins. Shortening of the telomeres occurs during genome
replication, thereby limiting the replication potential of somatic cells. To
counteract this shortening, vertebrates encode the telomerase complex that
maintains telomere length in certain cell types via de novo addition of
telomeric repeats. Several herpesviruses, including the highly oncogenic
alphaherpesvirus Marek’s disease virus (MDV), harbor telomeric repeats (TMR)
identical to the host telomere sequences at the ends of their linear genomes.
These TMR facilitate the integration of the MDV genome into host telomeres
during latency, allowing the virus to persist in the host for life.
Integration into host telomeres is critical for disease and tumor induction by
MDV, but also enables efficient reactivation of the integrated virus genome.
In addition to the TMR, MDV also encodes a telomerase RNA subunit (vTR) that
shares 88% sequence identity with the telomerase RNA in chicken (chTR). vTR is
highly expressed during all stages of the virus lifecycle, enhances telomerase
activity and plays an important role in MDV-induced tumor formation. This
review will focus on the recent advances in understanding the role of viral
TMR and vTR in MDV pathogenesis, integration and tumorigenesis.
en
dc.format.extent
13 Seiten
dc.rights.uri
http://creativecommons.org/licenses/by/4.0/
dc.subject
Marek’s disease virus (MDV)
dc.subject.ddc
600 Technik, Medizin, angewandte Wissenschaften::630 Landwirtschaft::630 Landwirtschaft und verwandte Bereiche
dc.title
Telomeres and telomerase: role in Marek's disease virus pathogenesis,
integration and tumorigenesis
dc.type
Wissenschaftlicher Artikel
dcterms.bibliographicCitation
Viruses 9 (2017), 7, Art. 173
dc.identifier.sepid
59778
dcterms.bibliographicCitation.doi
10.3390/v9070173
dcterms.bibliographicCitation.url
http://dx.doi.org/10.3390/v9070173
refubium.affiliation
Veterinärmedizin
de
refubium.affiliation.other
Institut für Virologie
refubium.funding
Deutsche Forschungsgemeinschaft (DFG)
refubium.mycore.fudocsId
FUDOCS_document_000000027626
refubium.note.author
Gefördert durch die DFG und den Open-Access-Publikationsfonds der Freien
Universität Berlin.
refubium.resourceType.isindependentpub
no
refubium.mycore.derivateId
FUDOCS_derivate_000000008647
dcterms.accessRights.openaire
open access
dcterms.isPartOf.issn
1999-4915