dc.contributor.author
Gambara, Guido
dc.contributor.author
Gaebler, Manuela
dc.contributor.author
Keilholz, Ulrich
dc.contributor.author
Regenbrecht, Christian R. A.
dc.contributor.author
Silvestri, Alessandra
dc.date.accessioned
2018-06-08T10:40:06Z
dc.date.available
2018-03-13T13:00:07.368Z
dc.identifier.uri
https://refubium.fu-berlin.de/handle/fub188/20851
dc.identifier.uri
http://dx.doi.org/10.17169/refubium-24150
dc.description.abstract
Recent advances in next-generation sequencing and other omics technologies
capable to map cell fate provide increasing evidence on the crucial role of
intra-tumor heterogeneity (ITH) for cancer progression. The different facets
of ITH, from genomic to microenvironmental heterogeneity and the hierarchical
cellular architecture originating from the cancer stem cell compartment,
contribute to the range of tumor phenotypes. Decoding these complex data
resulting from the analysis of tumor tissue complexity poses a challenge for
developing novel therapeutic strategies that can counteract tumor evolution
and cellular plasticity. To achieve this aim, the development of in vitro and
in vivo cancer models that resemble the complexity of ITH is crucial in
understanding the interplay of cells and their (micro)environment and,
consequently, in testing the efficacy of new targeted treatments and novel
strategies of tailoring combinations of treatments to the individual
composition of the tumor. This challenging approach may be an important
cornerstone in overcoming the development of pharmaco-resistances during
multiple lines of treatment. In this paper, we report the latest advances in
patient-derived 3D (PD3D) cell cultures and patient-derived tumor xenografts
(PDX) as in vitro and in vivo models that can retain the genetic and
phenotypic heterogeneity of the tumor tissue.
en
dc.format.extent
18 Seiten
dc.rights.uri
http://creativecommons.org/licenses/by/4.0/
dc.subject
PD3D cell culture
dc.subject
tumor heterogeneity
dc.subject
tumor microenvironment
dc.subject
tumor evolution
dc.subject
cancer stem cells
dc.subject.ddc
600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::616 Krankheiten
dc.subject.ddc
600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::614 Inzidenz und Prävention von Krankheiten
dc.title
From Chemotherapy to Combined Targeted Therapeutics
dc.type
Wissenschaftlicher Artikel
dcterms.bibliographicCitation
Frontiers in Pharmacology 9 (2018), Art. 77
dc.title.subtitle
in Vitro and in Vivo Models to Decipher Intra-tumor Heterogeneity
dcterms.bibliographicCitation.doi
10.3389/fphar.2018.00077
dcterms.bibliographicCitation.url
http://doi.org/10.3389/fphar.2018.00077
refubium.affiliation
Charité - Universitätsmedizin Berlin
de
refubium.mycore.fudocsId
FUDOCS_document_000000029298
refubium.note.author
Der Artikel wurde in einer Open-Access-Zeitschrift publiziert.
refubium.resourceType.isindependentpub
no
refubium.mycore.derivateId
FUDOCS_derivate_000000009530
dcterms.accessRights.openaire
open access
dcterms.isPartOf.issn
1663-9812