dc.contributor.author
Lofredi, Roxanne
dc.contributor.author
Neumann, Wolf-Julian
dc.contributor.author
Bock, Antje
dc.contributor.author
Horn, Andreas
dc.contributor.author
Huebl, Julius
dc.contributor.author
Siegert, Sandy
dc.contributor.author
Schneider, Gerd-Helge
dc.contributor.author
Krauss, Joachim K.
dc.contributor.author
Kühn, Andrea A.
dc.date.accessioned
2018-06-08T10:37:06Z
dc.date.available
2018-05-28T12:57:39.843Z
dc.identifier.uri
https://refubium.fu-berlin.de/handle/fub188/20760
dc.identifier.uri
http://dx.doi.org/10.17169/refubium-24059
dc.description.abstract
Gamma synchronization increases during movement and scales with kinematic
parameters. Here, disease-specific characteristics of this synchronization and
the dopamine-dependence of its scaling in Parkinson’s disease are
investigated. In 16 patients undergoing deep brain stimulation surgery,
movements of different velocities revealed that subthalamic gamma power peaked
in the sensorimotor part of the subthalamic nucleus, correlated positively
with maximal velocity and negatively with symptom severity. These effects
relied on movement-related bursts of transient synchrony in the gamma band.
The gamma burst rate highly correlated with averaged power, increased
gradually with larger movements and correlated with symptom severity. In the
dopamine-depleted state, gamma power and burst rate significantly decreased,
particularly when peak velocity was slower than ON medication. Burst amplitude
and duration were unaffected by the medication state. We propose that
insufficient recruitment of fast gamma bursts during movement may underlie
bradykinesia as one of the cardinal symptoms in Parkinson’s disease.
en
dc.format.extent
22 Seiten
dc.rights.uri
http://creativecommons.org/licenses/by/4.0/
dc.subject.ddc
600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::616 Krankheiten
dc.title
Dopamine-dependent scaling of subthalamic gamma bursts with movement velocity
in patients with Parkinson’s disease
dc.type
Wissenschaftlicher Artikel
dcterms.bibliographicCitation
eLIFE 7 (2018), e31895
dcterms.bibliographicCitation.doi
10.7554/eLife.31895
dcterms.bibliographicCitation.url
http://doi.org/10.7554/eLife.31895
refubium.affiliation
Charité - Universitätsmedizin Berlin
de
refubium.mycore.fudocsId
FUDOCS_document_000000029812
refubium.note.author
Der Artikel wurde in einer Open-Access-Zeitschrift publiziert.
refubium.resourceType.isindependentpub
no
refubium.mycore.derivateId
FUDOCS_derivate_000000009773
dcterms.accessRights.openaire
open access
dcterms.isPartOf.issn
2050-084X