dc.contributor.author
Swidsinski, Alexander
dc.contributor.author
Dörffel, Yvonne
dc.contributor.author
Loening-Baucke, Vera
dc.contributor.author
Gille, Christoph
dc.contributor.author
Göktas, Önder
dc.contributor.author
Reisshauer, Anne
dc.contributor.author
Neuhaus, Jürgen
dc.contributor.author
Weylandt, Karsten-Henrich
dc.contributor.author
Guschin, Alexander
dc.contributor.author
Bock, Markus
dc.date.accessioned
2018-06-08T10:34:01Z
dc.date.available
2017-08-28T09:46:29.119Z
dc.identifier.uri
https://refubium.fu-berlin.de/handle/fub188/20671
dc.identifier.uri
http://dx.doi.org/10.17169/refubium-23971
dc.description.abstract
Background: Colonic microbiome is thought to be involved in auto-immune
multiple sclerosis (MS). Interactions between diet and the colonic microbiome
in MS are unknown. Methods: We compared the composition of the colonic
microbiota quantitatively in 25 MS patients and 14 healthy
controls.Fluorescence in situ hybridization (FISH) with 162 ribosomal RNA
derived bacterial FISH probes was used. Ten of the MS patients received a
ketogenic diet for 6 months. Changes in concentrations of 35 numerically
substantial bacterial groups were monitored at baseline and at 2, 12, and
23/24 weeks. Results: No MS typical microbiome pattern was apparent.The total
concentrations and diversity of substantial bacterial groups were reduced in
MS patients (P < 0.001). Bacterial groups detected with EREC (mainly
Roseburia), Bac303 (Bacteroides), and Fprau (Faecalibacterium prausnitzii)
probes were diminished the most. The individual changes were multidirectional
and inconsistent. The effects of a ketogenic diet were biphasic. In the short
term, bacterial concentrations and diversity were further reduced. They
started to recover at week 12 and exceeded significantly the baseline values
after 23–24 weeks on the ketogenic diet. Conclusions: Colonic biofermentative
function is markedly impaired in MS patients.The ketogenic diet normalized
concentrations of the colonic microbiome after 6 months.
en
dc.rights.uri
http://creativecommons.org/licenses/by/4.0/
dc.subject
colonic microbiota
dc.subject
multiple sclerosis
dc.subject
biofermentation
dc.subject
ketogenic diet
dc.subject.ddc
600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit
dc.title
Reduced Mass and Diversity of the Colonic Microbiome in Patients with Multiple
Sclerosis and Their Improvement with Ketogenic Diet
dc.type
Wissenschaftlicher Artikel
dcterms.bibliographicCitation
Front. Microbiol. - 8 (2017), Artikel Nr. 1141
dcterms.bibliographicCitation.doi
10.3389/fmicb.2017.01141
dcterms.bibliographicCitation.url
http://doi.org/10.3389/fmicb.2017.01141
refubium.affiliation
Charité - Universitätsmedizin Berlin
de
refubium.mycore.fudocsId
FUDOCS_document_000000027674
refubium.note.author
Der Artikel wurde in einer reinen Open-Access-Zeitschrift publiziert.
refubium.resourceType.isindependentpub
no
refubium.mycore.derivateId
FUDOCS_derivate_000000008651
dcterms.accessRights.openaire
open access