dc.contributor.author
Hauner, Hans
dc.contributor.author
Hastreiter, Ljiljana
dc.contributor.author
Werdier, Dieter
dc.contributor.author
Chen-Stute, Annette
dc.contributor.author
Scholze, Jürgen
dc.contributor.author
Blüher, Matthias
dc.date.accessioned
2018-06-08T10:33:22Z
dc.date.available
2017-10-23T12:46:10.911Z
dc.identifier.uri
https://refubium.fu-berlin.de/handle/fub188/20647
dc.identifier.uri
http://dx.doi.org/10.17169/refubium-23948
dc.description.abstract
Objective: To investigate the efficacy and safety of increasing doses of
cathine (nor-pseudoephedrine) as a weight-lowering agent in patients with
obesity. Methods: Overweight and obese patients (n = 241, mean BMI 34.6 ± 3.4
kg/m²) were randomly allocated to one of three doses of cathine (16 mg, 32 mg,
53.3 mg) or placebo in addition to a multimodal lifestyle intervention program
in a multicenter, double-blind, controlled, dose-finding study for 24 weeks.
Primary outcome was weight loss. Results: Treatment with the 3 doses of
cathine resulted in a significantly greater weight loss compared to placebo
over 24 weeks: 6.5 ± 4.2 kg for 16 mg cathine, 6.2 ± 4.7 kg for 32 mg cathine,
and 9.1 ± 5.4 kg for 53.3 mg cathine versus 2.4 ± 4.4 kg for placebo (each p <
0.01, ANCOVA). The percentage of patients losing > 5% / >10% of initial body
weight was significantly greater for all doses of cathine than for placebo
(each p < 0.01, chi-square test). Heart rate increased dose-dependently (by
1.2 bpm under 16 mg, 5.8 bpm under 32 mg, and 6.2 bpm under 53.3 mg cathine),
but no suspected unexpected serious adverse reactions were noted. The overall
dropout rate was 24.9%, with the highest rate in the placebo group (42.3%).
Conclusion: Cathine appears to be an effective weight-lowering agent for
adjunct treatment of obesity, but additional clinical studies on its efficacy
and safety are required.
en
dc.format.extent
13 Seiten
dc.rights.uri
http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subject
Drug treatment
dc.subject
Dose-finding study
dc.subject.ddc
600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit
dc.subject.ddc
600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::616 Krankheiten
dc.title
Efficacy and Safety of Cathine (Nor-Pseudoephedrine) in the Treatment of
Obesity
dc.type
Wissenschaftlicher Artikel
dcterms.bibliographicCitation
Obesity Facts. - 10 (2017), S. 407-419
dc.title.subtitle
A Randomized Dose-Finding Study
dcterms.bibliographicCitation.doi
10.1159/000478098
dcterms.bibliographicCitation.url
http://doi.org/10.1159/000478098
refubium.affiliation
Charité - Universitätsmedizin Berlin
de
refubium.mycore.fudocsId
FUDOCS_document_000000028366
refubium.note.author
Der Artikel wurde in einer Open-Access-Zeitschrift publiziert.
refubium.resourceType.isindependentpub
no
refubium.mycore.derivateId
FUDOCS_derivate_000000009036
dcterms.accessRights.openaire
open access
dcterms.isPartOf.issn
1662-4033
dcterms.isPartOf.issn
1662-4025