dc.contributor.author
Stervbo, Ulrik
dc.contributor.author
Pohlmann, Dominika
dc.contributor.author
Baron, Udo
dc.contributor.author
Bozzetti, Cecilia
dc.contributor.author
Jürchott, Karsten
dc.contributor.author
Mälzer, Julia Nora
dc.contributor.author
Nienen, Mikalai
dc.contributor.author
Olek, Sven
dc.contributor.author
Roch, Toralf
dc.contributor.author
Schulz, Axel Ronald
dc.contributor.author
Warth, Sarah
dc.contributor.author
Neumann, Avidan
dc.contributor.author
Thiel, Andreas
dc.contributor.author
Grützkau, Andreas
dc.contributor.author
Babel, Nina
dc.date.accessioned
2018-06-08T10:25:40Z
dc.date.available
2017-08-23T08:29:25.746Z
dc.identifier.uri
https://refubium.fu-berlin.de/handle/fub188/20405
dc.identifier.uri
http://dx.doi.org/10.17169/refubium-23708
dc.description.abstract
Immunosenescence is a hallmark of the aging immune system and is considered
the main cause of a reduced vaccine efficacy in the elderly. Although γδ T
cells can become activated by recombinant influenza hemagglutinin, their age-
related immunocompetence during a virus-induced immune response has so far not
been investigated. In this study we evaluate the kinetics of γδ T cells after
vaccination with the trivalent 2011/2012 northern hemisphere seasonal
influenza vaccine. We applied multi-parametric flow cytometry to a cohort of
21 young (19–30 years) and 23 elderly (53–67 years) healthy individuals.
Activated and proliferating γδ T cells, as identified by CD38 and Ki67
expression, were quantified on the days 0, 3, 7, 10, 14, 17, and 21. We
observed a significantly lower number of activated and proliferating γδ T
cells at baseline and following vaccination in elderly as compared to young
individuals. The kinetics changes of activated γδ T cells were much stronger
in the young, while corresponding changes in the elderly occurred slower. In
addition, we observed an association between day 21 HAI titers of influenza A
and the frequencies of Ki67+ γδ T cells at day 7 in the young. In conclusion,
aging induces alterations of the γδ T cell response that might have negative
implications for vaccination efficacy.
en
dc.format.extent
14 Seiten
dc.rights.uri
http://creativecommons.org/licenses/by/4.0/
dc.subject
professional antigen-presentation
dc.subject
cytomegalovirus
dc.subject
neutralization
dc.subject.ddc
600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit
dc.title
Age dependent differences in the kinetics of γδ T cells after influenza
vaccination
dc.type
Wissenschaftlicher Artikel
dcterms.bibliographicCitation
PLOS ONE. - 12 (2017), 7, Artikel Nr. e0181161
dc.title.translated
Age dependent differences in the kinetics of Y delta T cells after influenza
vaccination
de
dcterms.bibliographicCitation.doi
10.1371/journal.pone.0181161
dcterms.bibliographicCitation.url
http://doi.org/10.1371/journal.pone.0181161
refubium.affiliation
Charité - Universitätsmedizin Berlin
de
refubium.mycore.fudocsId
FUDOCS_document_000000027612
refubium.note.author
Der Artikel wurde in einer reinen Open-Access-Zeitschrift publiziert.
refubium.resourceType.isindependentpub
no
refubium.mycore.derivateId
FUDOCS_derivate_000000008639
dcterms.accessRights.openaire
open access