dc.contributor.author
Gehring, Katrin B.
dc.contributor.author
Heufelder, Karin
dc.contributor.author
Depner, Harald
dc.contributor.author
Kersting, Isabella
dc.contributor.author
Sigrist, Stephan J.
dc.contributor.author
Eisenhardt, Dorothea
dc.date.accessioned
2018-06-08T10:22:58Z
dc.date.available
2017-10-26T09:17:13.994Z
dc.identifier.uri
https://refubium.fu-berlin.de/handle/fub188/20342
dc.identifier.uri
http://dx.doi.org/10.17169/refubium-23645
dc.description.abstract
In honeybees, age-associated structural modifications can be observed in the
mushroom bodies. Prominent examples are the synaptic complexes
(microglomeruli, MG) in the mushroom body calyces, which were shown to alter
their size and density with age. It is not known whether the amount of
intracellular synaptic proteins in the MG is altered as well. The presynaptic
protein Bruchpilot (BRP) is localized at active zones and is involved in
regulating the probability of neurotransmitter release in the fruit fly,
Drosophila melanogaster. Here, we explored the localization of the honeybee
BRP (Apis mellifera BRP, AmBRP) in the bee brain and examined age-related
changes in the AmBRP abundance in the central bee brain and in microglomeruli
of the mushroom body calyces. We report predominant AmBRP localization near
the membrane of presynaptic boutons within the mushroom body MG. The relative
amount of AmBRP was increased in the central brain of two-week old bees
whereas the amount of Synapsin, another presynaptic protein involved in the
regulation of neurotransmitter release, shows an increase during the first two
weeks followed by a decrease. In addition, we demonstrate an age-associated
modulation of AmBRP located near the membrane of presynaptic boutons within MG
located in mushroom body calyces where sensory input is conveyed to mushroom
body intrinsic neurons. We discuss that the observed age-associated AmBRP
modulation might be related to maturation processes or to homeostatic
mechanisms that might help to maintain synaptic functionality in old animals.
en
dc.format.extent
19 Seiten
dc.rights.uri
http://creativecommons.org/licenses/by/4.0/
dc.subject
honeybee mushroom body
dc.subject.ddc
500 Naturwissenschaften und Mathematik::570 Biowissenschaften; Biologie
dc.subject.ddc
500 Naturwissenschaften und Mathematik::570 Biowissenschaften; Biologie::573 Einzelne physiologische Systeme bei Tieren
dc.subject.ddc
500 Naturwissenschaften und Mathematik::590 Tiere (Zoologie)::595 Arthropoden (Gliederfüßer)
dc.title
Age-associated increase of the active zone protein Bruchpilot within the
honeybee mushroom body
dc.type
Wissenschaftlicher Artikel
dcterms.bibliographicCitation
PLoS ONE. - 12 (2017), 4, e0175894
dcterms.bibliographicCitation.doi
10.1371/journal.pone.0175894
dcterms.bibliographicCitation.url
http://doi.org/10.1371/journal.pone.0175894
refubium.affiliation
Biologie, Chemie, Pharmazie
de
refubium.affiliation.other
Institut für Biologie / Arbeitsbereich Neurobiologie
refubium.mycore.fudocsId
FUDOCS_document_000000028386
refubium.note.author
Der Artikel wurde in einer Open-Access-Zeitschrift publiziert.
refubium.resourceType.isindependentpub
no
refubium.mycore.derivateId
FUDOCS_derivate_000000009048
dcterms.accessRights.openaire
open access
dcterms.isPartOf.issn
1932-6203