dc.contributor.author
Seeland, Ute
dc.contributor.author
Brecht, Anna
dc.contributor.author
Nauman, Ahmad T.
dc.contributor.author
Oertelt-Prigione, Sabine
dc.contributor.author
Ruecke, Mirjam
dc.contributor.author
Knebel, Fabian
dc.contributor.author
Stangl, Verena
dc.contributor.author
Regitz-Zagrosek, Vera
dc.date.accessioned
2018-06-08T10:22:27Z
dc.date.available
2017-01-16T10:11:57.524Z
dc.identifier.uri
https://refubium.fu-berlin.de/handle/fub188/20318
dc.identifier.uri
http://dx.doi.org/10.17169/refubium-23621
dc.description.abstract
The present study determines the prevalence of vascular dysfunction and
arterial stiffness (ASt) in a female urban population by measuring the
brachial augmentation index (AIx) and aortic pulse wave velocity (PWV). The
study tests the hypothesis that the measurement of AIx and PWV is useful in
addition to that of traditional cardiovascular risk factors when assessing the
risk for left ventricular diastolic dysfunction (LVDD). This cross-sectional
study recruited 965 women aged 25–75 years from 12 districts of Berlin. The
ASt indices, brachial AIx, aortic PWV and the central blood pressure were
measured by an oscillometric method. A randomly selected subgroup (n=343) was
examined by echocardiography. Trans-mitral inflow E/A ratio and diastolic
mitral annulus velocity (é) were assessed. Questionnaires, medical history and
blood sampling were used for the evaluation of individual risk factors. Normal
vascular function was found in 55% of the women included. The prevalence of
women with pathological AIx only (AIx ⩾ −10%, PWV normal) was 21.5%, whereas
17.9% were affected by increased AIx and PWV (AIx ⩾ −10%, PWV ⩾9.7 m/s), and
6% with only pathological PWV values. The prevalence of LVDD was 31.7%. LVDD
was significantly associated with pathological PWV ⩾ 9.7 m/s [OR: 1.27, 95%CI:
1.02–1.57], age [OR: 4.17, 95%CI: 2.87–6.07] and a waist circumference >80 cm
[OR: 3.61, 95%CI: 1.85–7.04] in multiple regression analysis. The high
prevalence of markers for vascular dysfunction and ASt in a general female
population and their importance as a mediator of diastolic dysfunction should
encourage implementation of aortic PWV measurement to improve cardiovascular-
risk assessment in particular to identify subclinical myocardial diastolic
dysfunction.
en
dc.rights.uri
http://creativecommons.org/licenses/by/4.0/
dc.subject.ddc
600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit
dc.title
Prevalence of arterial stiffness and the risk of myocardial diastolic
dysfunction in women
dc.type
Wissenschaftlicher Artikel
dcterms.bibliographicCitation
Bioscience Reports. - 36 (2016), 5, Artikel Nr. e00400
dcterms.bibliographicCitation.doi
10.1042/BSR20160276
dcterms.bibliographicCitation.url
http://www.bioscirep.org/content/36/5/e00400
refubium.affiliation
Charité - Universitätsmedizin Berlin
de
refubium.mycore.fudocsId
FUDOCS_document_000000026151
refubium.note.author
Der Artikel wurde in einer reinen Open-Access-Zeitschrift publiziert.
refubium.resourceType.isindependentpub
no
refubium.mycore.derivateId
FUDOCS_derivate_000000007534
dcterms.accessRights.openaire
open access