dc.contributor.author
Friedrich, Stefanie
dc.contributor.author
Lüders, Susanne
dc.contributor.author
Werner, Stephanie Gabriele
dc.contributor.author
Glimm, Anne-Marie
dc.contributor.author
Burmester, Gerd-Rüdiger
dc.contributor.author
Riemekasten, Gabriela
dc.contributor.author
Backhaus, Marina
dc.contributor.author
Ohrndorf, Sarah
dc.date.accessioned
2018-06-08T10:22:17Z
dc.date.available
2017-06-08T10:02:36.000Z
dc.identifier.uri
https://refubium.fu-berlin.de/handle/fub188/20307
dc.identifier.uri
http://dx.doi.org/10.17169/refubium-23611
dc.description.abstract
Background Utilising fluorescence optical imaging (FOI), the distribution of
an intravenously applied colouring agent indocyanine green (ICG) can be
analysed with the potential to identify malperfusion by little to no tissue
enhancement. Systemic sclerosis (SSc) is characterised by the presence of
digital ulcers reflecting progressive vasculopathy. The objective was to
investigate the potential of FOI in the detection of disturbed
microcirculation in the hands and fingers of patients with SSc and to link FOI
findings to clinical signs of ischemia such as digital ulcers and pitting
scars. Methods In this cross-sectional study, 63 patients with SSc and 26
healthy subjects were examined. FOI was performed in all 89 individuals and
compared to clinical data and capillaroscopic findings assembled for the SSc
cohort. Results Healthy subjects showed initial ICG signals in their
fingertips in 93.6%, SSc patients in 78.5% (limited SSc) and 43.2% (diffuse
SSc). Moreover, in SSc patients, FOI findings were significantly associated
with a late capillaroscopic pattern, disseminated SSc features, a diffuse SSc
subtype, and the presence of digital ulcers or pitting scars. Intra- and
inter-reader reliability for FOI amounted to κ = 0.786 and κ = 0.834,
respectively. Conclusions FOI is able to detect areas of reduced
microcirculation in patients with SSc with high association to capillaroscopic
findings. The results pave the way for future FOI investigations into its role
in the prediction of complications due to an impaired acral perfusion.
en
dc.rights.uri
http://creativecommons.org/licenses/by/4.0/
dc.subject
Fluorescence optical imaging
dc.subject
Systemic sclerosis
dc.subject
Raynaud’s phenomenon
dc.subject
Disturbed microcirculation
dc.subject
Digital ulcers
dc.subject
Nailfold capillaroscopy
dc.subject.ddc
600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit
dc.title
Disturbed microcirculation in the hands of patients with systemic sclerosis
detected by fluorescence optical imaging
dc.type
Wissenschaftlicher Artikel
dcterms.bibliographicCitation
Arthritis Research & Therapy. - 19 (2017), Artikel Nr. 87
dc.title.subtitle
a pilot study
dcterms.bibliographicCitation.doi
10.1186/s13075-017-1300-6
dcterms.bibliographicCitation.url
http://arthritis-research.biomedcentral.com/articles/10.1186/s13075-017-1300-6
refubium.affiliation
Charité - Universitätsmedizin Berlin
de
refubium.mycore.fudocsId
FUDOCS_document_000000027147
refubium.note.author
Der Artikel wurde in einer reinen Open-Access-Zeitschrift publiziert.
refubium.resourceType.isindependentpub
no
refubium.mycore.derivateId
FUDOCS_derivate_000000008291
dcterms.accessRights.openaire
open access