dc.contributor.author
Theilig, Dorothea
dc.contributor.author
Doellinger, Felix
dc.contributor.author
Poellinger, Alexander
dc.contributor.author
Schreiter, Vera
dc.contributor.author
Neumann, Konrad
dc.contributor.author
Hubner, Ralf-Harto
dc.date.accessioned
2018-06-08T10:19:57Z
dc.date.available
2017-06-28T12:12:18.406Z
dc.identifier.uri
https://refubium.fu-berlin.de/handle/fub188/20256
dc.identifier.uri
http://dx.doi.org/10.17169/refubium-23560
dc.description.abstract
Background: The degree of interlobar emphysema heterogeneity is thought to
play an important role in the outcome of endoscopic lung volume reduction
(ELVR) therapy of patients with advanced COPD. There are multiple ways one
could possibly define interlobar emphysema heterogeneity, and there is no
standardized definition. Purpose: The aim of this study was to derive a
formula for calculating an interlobar emphysema heterogeneity index (HI) when
evaluating a patient for ELVR. Furthermore, an attempt was made to identify a
threshold for relevant interlobar emphysema heterogeneity with regard to ELVR.
Patients and methods: We retrospectively analyzed 50 patients who had
undergone technically successful ELVR with placement of one-way valves at our
institution and had received lung function tests and computed tomography scans
before and after treatment. Predictive accuracy of the different methods for
HI calculation was assessed with receiver-operating characteristic curve
analysis, assuming a minimum difference in forced expiratory volume in 1
second of 100 mL to indicate a clinically important change. Results: The HI
defined as emphysema score of the targeted lobe (TL) minus emphysema score of
the ipsilateral nontargeted lobe disregarding the middle lobe yielded the best
predicative accuracy (AUC =0.73, P=0.008). The HI defined as emphysema score
of the TL minus emphysema score of the lung without the TL showed a similarly
good predictive accuracy (AUC =0.72, P=0.009). Subgroup analysis suggests that
the impact of interlobar emphysema heterogeneity is of greater importance in
patients with upper lobe predominant emphysema than in patients with lower
lobe predominant emphysema. Conclusion: This study reveals the most
appropriate ways of calculating an interlobar emphysema heterogeneity with
regard to ELVR.
en
dc.rights.uri
http://creativecommons.org/licenses/by-nc/3.0/
dc.subject
CT-quantitative
dc.subject
emphysema heterogeneity
dc.subject
endoscopic lung volume reduction
dc.subject.ddc
600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit
dc.title
Comparison of distinctive models for calculating an interlobar emphysema
heterogeneity index in patients prior to endoscopic lung volume reduction
dc.type
Wissenschaftlicher Artikel
dcterms.bibliographicCitation
International Journal of Chronic Obstructive Pulmonary Disease. - 12 (2017),
S. 1631-1640
dcterms.bibliographicCitation.doi
10.2147/COPD.S133348
dcterms.bibliographicCitation.url
http://doi.org/10.2147/COPD.S133348
refubium.affiliation
Charité - Universitätsmedizin Berlin
de
refubium.mycore.fudocsId
FUDOCS_document_000000027266
refubium.note.author
Der Artikel wurde in einer reinen Open-Access-Zeitschrift publiziert.
refubium.resourceType.isindependentpub
no
refubium.mycore.derivateId
FUDOCS_derivate_000000008378
dcterms.accessRights.openaire
open access