dc.contributor.author
Villringer, Kersten
dc.contributor.author
Grittner, Ulrike
dc.contributor.author
Schaafs, Lars-Arne
dc.contributor.author
Nolte, Christian H.
dc.contributor.author
Audebert, Heinrich
dc.contributor.author
Fiebach, Jochen B.
dc.date.accessioned
2018-06-08T04:22:21Z
dc.date.available
2014-12-09T09:11:17.335Z
dc.identifier.uri
https://refubium.fu-berlin.de/handle/fub188/17160
dc.identifier.uri
http://dx.doi.org/10.17169/refubium-21340
dc.description.abstract
Background There is an ongoing debate whether stroke patients presenting with
minor or moderate symptoms benefit from thrombolysis. Up until now, stroke
severity on admission is typically measured with the NIHSS, and subsequently
used for treatment decision. Hypothesis Acute MRI lesion volume assessment can
aid in therapy decision for iv-tPA in minor stroke. Methods We analysed 164
patients with NIHSS 0–7 from a prospective stroke MRI registry, the 1000+
study (clinicaltrials.org NCT00715533). Patients were examined in a 3 T MRI
scanner and either received (n = 62) or did not receive thrombolysis (n =
102). DWI (diffusion weighted imaging) and PI (perfusion imaging) at admission
were evaluated for diffusion - perfusion mismatch. Our primary outcome
parameter was final lesion volume, defined by lesion volume on day 6 FLAIR
images. Results The association between t-PA and FLAIR lesion volume on day 6
was significantly different for patients with smaller DWI volume compared to
patients with larger DWI volume (interaction between DWI and t-PA: p = 0.021).
Baseline DWI lesion volume was dichotomized at the median (0.7 ml): final
lesion volume at day 6 was larger in patients with large baseline DWI volumes
without t-PA treatment (median difference 3, IQR −0.4–9.3 ml). Conversely, in
patients with larger baseline DWI volumes final lesion volumes were smaller
after t-PA treatment (median difference 0, IQR −4.1–5 ml). However, this did
not translate into a significant difference in the mRS at day 90 (p = 0.577).
Conclusion Though this study is only hypothesis generating considering the
number of cases, we believe that the size of DWI lesion volume may support
therapy decision in patients with minor stroke.
en
dc.rights.uri
http://creativecommons.org/licenses/by/4.0/
dc.subject.ddc
600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit
dc.title
IV t-PA Influences Infarct Volume in Minor Stroke
dc.type
Wissenschaftlicher Artikel
dcterms.bibliographicCitation
PLoS ONE. - 9 (2014), 10, Artikel Nr. e110477
dc.title.subtitle
A Pilot Study
dcterms.bibliographicCitation.doi
10.1371/journal.pone.0110477
dcterms.bibliographicCitation.url
http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0110477
refubium.affiliation
Charité - Universitätsmedizin Berlin
de
refubium.mycore.fudocsId
FUDOCS_document_000000021418
refubium.note.author
Der Artikel wurde in einer Open-Access-Zeitschrift publiziert.
refubium.resourceType.isindependentpub
no
refubium.mycore.derivateId
FUDOCS_derivate_000000004232
dcterms.accessRights.openaire
open access