dc.contributor.author
Siramshetty, Vishal B.
dc.contributor.author
Nickel, Janette
dc.contributor.author
Omieczynski, Christian
dc.contributor.author
Gohlke, Bjoern-Oliver
dc.contributor.author
Drwal, Malgorzata N.
dc.contributor.author
Preissner, Robert
dc.date.accessioned
2018-06-08T04:18:52Z
dc.date.available
2016-04-11T10:34:18.262Z
dc.identifier.uri
https://refubium.fu-berlin.de/handle/fub188/17031
dc.identifier.uri
http://dx.doi.org/10.17169/refubium-21211
dc.description.abstract
Post-marketing drug withdrawals can be associated with various events, ranging
from safety issues such as reported deaths or severe side-effects, to a
multitude of non-safety problems including lack of efficacy, manufacturing,
regulatory or business issues. During the last century, the majority of drugs
voluntarily withdrawn from the market or prohibited by regulatory agencies was
reported to be related to adverse drug reactions. Understanding the underlying
mechanisms of toxicity is of utmost importance for current and future drug
discovery. Here, we present WITHDRAWN, a resource for withdrawn and
discontinued drugs publicly accessible at
http://cheminfo.charite.de/withdrawn. Today, the database comprises 578
withdrawn or discontinued drugs, their structures, important physico-chemical
properties, protein targets and relevant signaling pathways. A special focus
of the database lies on the drugs withdrawn due to adverse reactions and toxic
effects. For approximately one half of the drugs in the database, safety
issues were identified as the main reason for withdrawal. Withdrawal reasons
were extracted from the literature and manually classified into toxicity types
representing adverse effects on different organs. A special feature of the
database is the presence of multiple search options which will allow
systematic analyses of withdrawn drugs and their mechanisms of toxicity.
en
dc.rights.uri
http://creativecommons.org/licenses/by-nc/4.0/
dc.subject.ddc
600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit
dc.title
WITHDRAWN - a resource for withdrawn and discontinued drugs
dc.type
Wissenschaftlicher Artikel
dcterms.bibliographicCitation
Nucleic Acids Research. - 44 (2016), D1, S. D1080-D1086
dcterms.bibliographicCitation.doi
10.1093/nar/gkv1192
dcterms.bibliographicCitation.url
http://nar.oxfordjournals.org/content/44/D1/D1080
refubium.affiliation
Charité - Universitätsmedizin Berlin
de
refubium.mycore.fudocsId
FUDOCS_document_000000024351
refubium.note.author
Der Artikel wurde in einer Open-Access-Zeitschrift publiziert.
refubium.resourceType.isindependentpub
no
refubium.mycore.derivateId
FUDOCS_derivate_000000006265
dcterms.accessRights.openaire
open access