dc.contributor.author
Veletzky, Luzia
dc.contributor.author
Rehman, Khalid
dc.contributor.author
Lingscheid, Tilman
dc.contributor.author
Poeppl, Wolfgang
dc.contributor.author
Burgmann, Heinz
dc.contributor.author
Ramharter, Michael
dc.date.accessioned
2018-06-08T04:16:57Z
dc.date.available
2015-01-13T10:36:27.759Z
dc.identifier.uri
https://refubium.fu-berlin.de/handle/fub188/16966
dc.identifier.uri
http://dx.doi.org/10.17169/refubium-21147
dc.description.abstract
Background Solid organ transplant recipients are particularly vulnerable for
infectious diseases due to prolonged immunosuppressive treatment. Residents of
endemic regions and travellers may be exposed to malaria and may, therefore,
require prolonged antimalarial chemoprophylaxis. The hypothesis of this study
was that certain immunosuppressive drugs may exert clinically relevant anti-
malarial activity. It was therefore designed to assess the intrinsic anti-
malarial activity of everolimus, mycophenolic acid, and rapamycin against
Plasmodium falciparum in an in vitro model. Methods Three laboratory adapted
clones of P. falciparum and two isolates were used to assess the potential of
mycophenolic acid, rapamycin and everolimus to inhibit in vitro growth of P.
falciparum. The standard histidine rich protein 2 assay was employed and
inhibitory drug concentrations (IC) were computed by non-linear regression
analysis. Results All drugs were associated with complete inhibition of P.
falciparum growth in in vitro assays. Mycophenolic acid demonstrated IC50 and
IC90 values of 5.4 μmol/L and 15.3 μmol/L. Rapamycin inhibited P. falciparum
growth at 7.2 μmol/L (IC50) and 12.5 μmol/L (IC90), respectively. Finally,
everolimus displayed IC50 and IC90 values of 6.2 μmol/L and 11.5 μmol/L. There
was no difference in in vitro activity against chloroquine sensitive or
chloroquine resistant parasites. Conclusions All immunosuppressive drugs
evaluated in this in vitro study demonstrated activity against P. falciparum.
Inhibitory concentrations of mycophenolic acid are within clinically
achievable plasma concentrations when used in solid organ transplant
recipients. Further in vivo evaluation of mycophenolic acid either alone or in
combination regimens may prove promising for the concomitant prevention of P.
falciparum in solid organ transplant recipients living or travelling in
malaria endemic regions.
en
dc.rights.uri
http://creativecommons.org/licenses/by/4.0/
dc.subject.ddc
600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::616 Krankheiten
dc.title
In vitro activity of immunosuppressive drugs against Plasmodium falciparum
dc.type
Wissenschaftlicher Artikel
dcterms.bibliographicCitation
Malaria Journal. - 13 (2014), 1, Artikel Nr. 476
dcterms.bibliographicCitation.doi
10.1186/1475-2875-13-476
dcterms.bibliographicCitation.url
http://www.malariajournal.com/content/13/1/476
refubium.affiliation
Charité - Universitätsmedizin Berlin
de
refubium.mycore.fudocsId
FUDOCS_document_000000021571
refubium.note.author
Der Artikel wurde in einer Open-Access-Zeitschrift publiziert.
refubium.resourceType.isindependentpub
no
refubium.mycore.derivateId
FUDOCS_derivate_000000004359
dcterms.accessRights.openaire
open access