dc.contributor.author
Sothmann, Peter
dc.contributor.author
Krumkamp, Ralf
dc.contributor.author
Kreuels, Benno
dc.contributor.author
Sarpong, Nimako
dc.contributor.author
Frank, Clemens
dc.contributor.author
Ehlkes, Lutz
dc.contributor.author
Fobil, Julius
dc.contributor.author
Gyau, Kennedy
dc.contributor.author
Jaeger, Anna
dc.contributor.author
Bosu, Benedicta
dc.contributor.author
Marks, Florian
dc.contributor.author
Owusu-Dabo, Ellis
dc.contributor.author
Salzberger, Bernd
dc.contributor.author
May, Jürgen
dc.date.accessioned
2018-06-08T04:14:21Z
dc.date.available
2015-11-02T09:42:24.633Z
dc.identifier.uri
https://refubium.fu-berlin.de/handle/fub188/16875
dc.identifier.uri
http://dx.doi.org/10.17169/refubium-21056
dc.description.abstract
Background Systemic bacterial infections are a major cause of paediatric
febrile illness in sub-Saharan Africa. Aim of this study was to assess the
effects of social and geographical determinants on the risk of bacteraemia in
a rural-urban transition zone in Ghana. Methods Children below 15 years of age
with fever were recruited at an outpatient department in the suburban belt of
Kumasi, Ghana’s second largest city. Blood was taken for bacterial culture and
malaria diagnostics. The socio-economic status of participants was calculated
using Principle Component Analysis. A scale, based on key urban
characteristics, was established to quantify urbanicity for all communities in
the hospital catchment area. A case-control analysis was conducted, where
children with and without bacteraemia were cases and controls, respectively.
Results Bacteraemia was detected in 72 (3.1%) of 2,306 hospital visits. Non-
typhoidal Salmonella (NTS; n = 24; 33.3%) and Salmonella typhi (n = 18; 25.0%)
were the most common isolates. Logistic regression analysis showed that
bacteraemia was negatively associated with urbanicity (odds ratio [OR] = 0.8;
95% confidence interval [CI]: 0.7–1.0) and socio-economic status (OR = 0.8;
95% CI: 0.6–0.9). Both associations were stronger if only NTS infections were
used as cases (OR = 0.5; 95% CI: 0.3–0.8 and OR = 0.6; 95% CI: 0.4–1.0,
respectively). Conclusions The results of this study highlight the importance
of individual as well as community factors as independent risk factors for
invasive bacterial infection (IBI) and especially NTS. Epidemiological data
support physicians, public health experts and policy makers to identify
disease prevention and treatment needs in order to secure public health in the
transitional societies of developing countries.
en
dc.rights.uri
http://creativecommons.org/licenses/by/4.0/
dc.subject.ddc
600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit
dc.title
Urbanicity and Paediatric Bacteraemia in Ghana - A Case-Control Study within a
Rural-Urban Transition Zone
dc.type
Wissenschaftlicher Artikel
dcterms.bibliographicCitation
PLoS ONE. - 10 (2015), 9, Artikel Nr. e0139433
dcterms.bibliographicCitation.doi
10.1371/journal.pone.0139433
dcterms.bibliographicCitation.url
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0139433
refubium.affiliation
Charité - Universitätsmedizin Berlin
de
refubium.mycore.fudocsId
FUDOCS_document_000000023392
refubium.note.author
Der Artikel wurde in einer Open-Access-Zeitschrift publiziert.
refubium.resourceType.isindependentpub
no
refubium.mycore.derivateId
FUDOCS_derivate_000000005609
dcterms.accessRights.openaire
open access