dc.contributor.author
Koelzer, Viktor H.
dc.contributor.author
Herrmann, Pia
dc.contributor.author
Zlobec, Inti
dc.contributor.author
Karamitopoulou, Eva
dc.contributor.author
Lugli, Alessandro
dc.contributor.author
Stein, Ulrike
dc.date.accessioned
2018-06-08T04:13:26Z
dc.date.available
2015-04-22T06:25:09.629Z
dc.identifier.uri
https://refubium.fu-berlin.de/handle/fub188/16842
dc.identifier.uri
http://dx.doi.org/10.17169/refubium-21023
dc.description.abstract
Background Metastasis of colorectal cancer (CRC) is directly linked to patient
survival. We previously identified the novel gene Metastasis Associated in
Colon Cancer 1 (MACC1) in CRC and demonstrated its importance as metastasis
inducer and prognostic biomarker. Here, we investigate the geographic
expression pattern of MACC1 in colorectal adenocarcinoma and tumor buds in
correlation with clinicopathological and molecular features for improvement of
survival prognosis. Methods We performed geographic MACC1 expression analysis
in tumor center, invasive front and tumor buds on whole tissue sections of 187
well-characterized CRCs by immunohistochemistry. MACC1 expression in each
geographic zone was analyzed with Mismatch repair (MMR)-status, BRAF/KRAS-
mutations and CpG-island methylation. Results MACC1 was significantly
overexpressed in tumor tissue as compared to normal mucosa (p < 0.001). Within
colorectal adenocarcinomas, a significant increase of MACC1 from tumor center
to front (p = 0.0012) was detected. MACC1 was highly overexpressed in 55%
tumor budding cells. Independent of geographic location, MACC1 predicted
advanced pT and pN-stages, high grade tumor budding, venous and lymphatic
invasion (p < 0.05). High MACC1 expression at the invasive front was decisive
for prediction of metastasis (p = 0.0223) and poor survival (p = 0.0217). The
geographic pattern of MACC1 did not correlate with MMR-status, BRAF/KRAS-
mutations or CpG-island methylation. Conclusion MACC1 is differentially
expressed in CRC. At the invasive front, MACC1 expression predicts best
aggressive clinicopathological features, tumor budding, metastasis formation
and poor survival outcome.
de
dc.rights.uri
http://creativecommons.org/licenses/by/4.0/
dc.subject
Colorectal cancer
dc.subject
Prognostic factor
dc.subject.ddc
600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit
dc.title
Heterogeneity analysis of Metastasis Associated in Colon Cancer 1 (MACC1) for
survival prognosis of colorectal cancer patients
dc.type
Wissenschaftlicher Artikel
dcterms.bibliographicCitation
BMC Cancer. - 15 (2015), Artikel Nr. 160
dc.title.subtitle
a retrospective cohort study
dcterms.bibliographicCitation.doi
10.1186/s12885-015-1150-z
dcterms.bibliographicCitation.url
http://www.biomedcentral.com/1471-2407/15/160
refubium.affiliation
Charité - Universitätsmedizin Berlin
de
refubium.mycore.fudocsId
FUDOCS_document_000000022248
refubium.note.author
Der Artikel wurde in einer Open-Access-Zeitschrift publiziert.
refubium.resourceType.isindependentpub
no
refubium.mycore.derivateId
FUDOCS_derivate_000000004795
dcterms.accessRights.openaire
open access