dc.contributor.author
McQuade, D. Tyler
dc.contributor.author
O'Brien, Alexander G.
dc.contributor.author
Dörr, Markus
dc.contributor.author
Rajaratnam, Rajathees
dc.contributor.author
Eisold, Ursula
dc.contributor.author
Monnanda, Bopanna
dc.contributor.author
Nobuta, Tomoya
dc.contributor.author
Löhmannsröben, Hans-Gerd
dc.contributor.author
Meggers, Eric
dc.contributor.author
Seeberger, Peter H.
dc.date.accessioned
2018-06-08T04:10:48Z
dc.date.available
2016-09-28T12:20:21.719Z
dc.identifier.uri
https://refubium.fu-berlin.de/handle/fub188/16745
dc.identifier.uri
http://dx.doi.org/10.17169/refubium-20926
dc.description.abstract
Pyridocarbazoles when ligated to transition metals yield high affinity kinase
inhibitors. While batch photocyclizations enable the synthesis of these
heterocycles, the non-oxidative Mallory reaction only provides modest yields
and difficult to purify mixtures. We demonstrate here that a flow-based
Mallory cyclization provides superior results and enables observation of a
clear isobestic point. The flow method allowed us to rapidly synthesize ten
pyridocarbazoles and for the first time to document their interesting
photophysical attributes. Preliminary characterization reveals that these
molecules might be a new class of fluorescent bioprobe.
en
dc.rights.uri
http://www.rsc.org/journals-books-databases/open-access/green-open-access/
dc.subject.ddc
500 Naturwissenschaften und Mathematik::540 Chemie
dc.title
Continuous synthesis of pyridocarbazoles and initial photophysical and
bioprobe characterization
dc.type
Wissenschaftlicher Artikel
dcterms.bibliographicCitation
Chemical Science. - 4 (2013), 10, S. 4067-4070
dcterms.bibliographicCitation.doi
10.1039/C3SC51846A
dcterms.bibliographicCitation.url
http://pubs.rsc.org/en/content/articlelanding/2013/sc/c3sc51846a#!divAbstract
refubium.affiliation
Biologie, Chemie, Pharmazie
de
refubium.mycore.fudocsId
FUDOCS_document_000000025441
refubium.resourceType.isindependentpub
no
refubium.mycore.derivateId
FUDOCS_derivate_000000007147
dcterms.accessRights.openaire
open access