dc.contributor.author
Franzoni, Eleonora
dc.contributor.author
Booker, Sam A.
dc.contributor.author
Parthasarathy, Srinivas
dc.contributor.author
Rehfeld, Frederick
dc.contributor.author
Grosser, Sabine
dc.contributor.author
Srivatsa, Swathi
dc.contributor.author
Fuchs, Heiko R.
dc.contributor.author
Tarabykin, Victor
dc.contributor.author
Vida, Imre
dc.contributor.author
Wulczyn, F. Gregory
dc.date.accessioned
2018-06-08T04:09:53Z
dc.date.available
2015-02-05T13:14:05.751Z
dc.identifier.uri
https://refubium.fu-berlin.de/handle/fub188/16702
dc.identifier.uri
http://dx.doi.org/10.17169/refubium-20883
dc.description.abstract
miR-128, a brain-enriched microRNA, has been implicated in the control of
neurogenesis and synaptogenesis but its potential roles in intervening
processes have not been addressed. We show that post-transcriptional
mechanisms restrict miR-128 accumulation to post-mitotic neurons during mouse
corticogenesis and in adult stem cell niches. Whereas premature miR-128
expression in progenitors for upper layer neurons leads to impaired neuronal
migration and inappropriate branching, sponge-mediated inhibition results in
overmigration. Within the upper layers, premature miR-128 expression reduces
the complexity of dendritic arborization, associated with altered
electrophysiological properties. We show that Phf6, a gene mutated in the
cognitive disorder Börjeson-Forssman-Lehmann syndrome, is an important
regulatory target for miR-128. Restoring PHF6 expression counteracts the
deleterious effect of miR-128 on neuronal migration, outgrowth and intrinsic
physiological properties. Our results place miR-128 upstream of PHF6 in a
pathway vital for cortical lamination as well as for the development of
neuronal morphology and intrinsic excitability.
en
dc.rights.uri
http://creativecommons.org/licenses/by/4.0/
dc.subject.ddc
600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit
dc.title
miR-128 regulates neuronal migration, outgrowth and intrinsic excitability via
the intellectual disability gene Phf6
dc.type
Wissenschaftlicher Artikel
dcterms.bibliographicCitation
ELIFE. - 4 (2015), 59 S.
dcterms.bibliographicCitation.doi
10.7554/eLife.04263
dcterms.bibliographicCitation.url
http://dx.doi.org/10.7554/eLife.04263
refubium.affiliation
Charité - Universitätsmedizin Berlin
de
refubium.mycore.fudocsId
FUDOCS_document_000000021771
refubium.note.author
Der Artikel wurde in einer Open-Access-Zeitschrift publiziert.
refubium.resourceType.isindependentpub
no
refubium.mycore.derivateId
FUDOCS_derivate_000000004479
dcterms.accessRights.openaire
open access