dc.contributor.author
Wojtecki, Lars
dc.contributor.author
Elben, Saskia
dc.contributor.author
Timmermann, Lars
dc.contributor.author
Reck, Christiane
dc.contributor.author
Maarouf, Mohammad
dc.contributor.author
Jörgens, Silke
dc.contributor.author
Ploner, Markus
dc.contributor.author
Südmeyer, Martin
dc.contributor.author
Groiss, Stefan Jun
dc.contributor.author
Sturm, Volker
dc.contributor.author
Niedeggen, Michael
dc.contributor.author
Schnitzler, Alfons
dc.date.accessioned
2018-06-08T04:07:59Z
dc.date.available
2013-05-23T13:19:19.166Z
dc.identifier.uri
https://refubium.fu-berlin.de/handle/fub188/16644
dc.identifier.uri
http://dx.doi.org/10.17169/refubium-20825
dc.description.abstract
Timing in the range of seconds referred to as interval timing is crucial for
cognitive operations and conscious time processing. According to recent models
of interval timing basal ganglia (BG) oscillatory loops are involved in time
interval recognition. Parkinsońs disease (PD) is a typical disease of the
basal ganglia that shows distortions in interval timing. Deep brain
stimulation (DBS) of the subthalamic nucleus (STN) is a powerful treatment of
PD which modulates motor and cognitive functions depending on stimulation
frequency by affecting subcortical-cortical oscillatory loops. Thus, for the
understanding of BG-involvement in interval timing it is of interest whether
STN-DBS can modulate timing in a frequency dependent manner by interference
with oscillatory time recognition processes. We examined production and
reproduction of 5 and 15 second intervals and millisecond timing in a double
blind, randomised, within-subject repeated-measures design of 12 PD-patients
applying no, 10-Hz- and ≥130-Hz-STN-DBS compared to healthy controls. We found
under(re-)production of the 15-second interval and a significant enhancement
of this under(re-)production by 10-Hz-stimulation compared to no stimulation,
≥130-Hz-STN-DBS and controls. Milliseconds timing was not affected. We provide
first evidence for a frequency-specific modulatory effect of STN-DBS on
interval timing. Our results corroborate the involvement of BG in general and
of the STN in particular in the cognitive representation of time intervals in
the range of multiple seconds.
en
dc.rights.uri
http://www.fu-berlin.de/sites/refubium/rechtliches/Nutzungsbedingungen
dc.subject.ddc
100 Philosophie und Psychologie::150 Psychologie::153 Kognitive Prozesse, Intelligenz
dc.title
Modulation of Human Time Processing by Subthalamic Deep Brain Stimulation
dc.type
Wissenschaftlicher Artikel
dcterms.bibliographicCitation
PLoS ONE 6 (2011), 9, e24589
dcterms.bibliographicCitation.doi
10.1371/journal.pone.0024589
dcterms.bibliographicCitation.url
http://doi.org/10.1371/journal.pone.0024589
refubium.affiliation
Erziehungswissenschaft und Psychologie
de
refubium.affiliation.other
Arbeitsbereich Allgemeine Psychologie und Neuropsychologie

refubium.mycore.fudocsId
FUDOCS_document_000000017583
refubium.note.author
Copyright: © 2011 Wojtecki et al. This is an open-access article distributed
under the terms of the Creative Commons Attribution License, which permits
unrestricted use, distribution, and reproduction in any medium, provided the
original author and source are credited. (Der Artikel wurde in einer Open-
Access-Zeitschrift publiziert.)
refubium.resourceType.isindependentpub
no
refubium.mycore.derivateId
FUDOCS_derivate_000000002529
dcterms.accessRights.openaire
open access