dc.contributor.author
Moseley, Rachel L.
dc.contributor.author
Correia, Marta M.
dc.contributor.author
Baron-Cohen, Simon
dc.contributor.author
Shtyrov, Yury
dc.contributor.author
Pulvermueller, Friedemann
dc.contributor.author
Mohr, Bettina
dc.date.accessioned
2018-06-08T04:07:20Z
dc.date.available
2016-06-13T11:33:20.049Z
dc.identifier.uri
https://refubium.fu-berlin.de/handle/fub188/16606
dc.identifier.uri
http://dx.doi.org/10.17169/refubium-20787
dc.description.abstract
Atypical language is a fundamental feature of autism spectrum conditions
(ASC), but few studies have examined the structural integrity of the arcuate
fasciculus, the major white matter tract connecting frontal and temporal
language regions, which is usually implicated as the main transfer route used
in processing linguistic information by the brain. Abnormalities in the
arcuate have been reported in young children with ASC, mostly in low-
functioning or non-verbal individuals, but little is known regarding the
structural properties of the arcuate in adults with ASC or, in particular, in
individuals with ASC who have intact language, such as those with high-
functioning autism or Asperger syndrome. We used probabilistic tractography of
diffusion-weighted imaging to isolate and scrutinize the arcuate in a mixed-
gender sample of 18 high-functioning adults with ASC (17 Asperger syndrome)
and 14 age- and IQ-matched typically developing controls. Arcuate volume was
significantly reduced bilaterally with clearest differences in the right
hemisphere. This finding remained significant in an analysis of all male
participants alone. Volumetric reduction in the arcuate was significantly
correlated with the severity of autistic symptoms as measured by the Autism-
Spectrum Quotient. These data reveal that structural differences are present
even in high-functioning adults with ASC, who presented with no clinically
manifest language deficits and had no reported developmental language delay.
Arcuate structural integrity may be useful as an index of ASC severity and
thus as a predictor and biomarker for ASC. Implications for future research
are discussed.
en
dc.rights.uri
http://creativecommons.org/licenses/by/4.0/
dc.subject
Asperger syndrome
dc.subject
diffusion-weighted imaging (DWI)
dc.subject
arcuate fasciculus
dc.subject.ddc
600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit
dc.title
Reduced Volume of the Arcuate Fasciculus in Adults with High-Functioning
Autism Spectrum Conditions
dc.type
Wissenschaftlicher Artikel
dcterms.bibliographicCitation
Front. Hum. Neurosci. - 10 (2016), Artikel Nr. 214
dcterms.bibliographicCitation.doi
10.3389/fnhum.2016.00214
dcterms.bibliographicCitation.url
http://dx.doi.org/10.3389/fnhum.2016.00214
refubium.affiliation
Philosophie und Geisteswissenschaften
de
refubium.mycore.fudocsId
FUDOCS_document_000000024768
refubium.note.author
Der Artikel wurde in einer Open-Access-Zeitschrift publiziert.
refubium.resourceType.isindependentpub
no
refubium.mycore.derivateId
FUDOCS_derivate_000000006576
dcterms.accessRights.openaire
open access