dc.contributor.author
Kostadinova, Elena
dc.contributor.author
Chaput, Catherine
dc.contributor.author
Gutbier, Birgitt
dc.contributor.author
Lippmann, Juliane
dc.contributor.author
Sander, Leif E.
dc.contributor.author
Mitchell, Timothy J.
dc.contributor.author
Suttorp, Norbert
dc.contributor.author
Witzenrath, Martin
dc.contributor.author
Opitz, Bastian
dc.date.accessioned
2018-06-08T04:06:10Z
dc.date.available
2016-09-19T10:05:46.931Z
dc.identifier.uri
https://refubium.fu-berlin.de/handle/fub188/16579
dc.identifier.uri
http://dx.doi.org/10.17169/refubium-20760
dc.description.abstract
Bacterial pneumonia is a major cause of acute lung injury and acute
respiratory distress syndrome, characterized by alveolar barrier disruption.
NLRP3 is best known for its ability to form inflammasomes and to regulate IL-
1β and IL-18 production in myeloid cells. Here we show that NLRP3 protects the
integrity of the alveolar barrier in a mouse model of Streptococcus
pneumoniae-induced pneumonia, and ex vivo upon treatment of isolated perfused
and ventilated lungs with the purified bacterial toxin, pneumolysin. We reveal
that the preserving effect of NLRP3 on the lung barrier is independent of
inflammasomes, IL-1β and IL-18. NLRP3 improves the integrity of alveolar
epithelial cell monolayers by enhancing cellular adherence. Collectively, our
study uncovers a novel function of NLRP3 by demonstrating that it protects
epithelial barrier function independently of inflammasomes.
en
dc.rights.uri
http://creativecommons.org/licenses/by/4.0/
dc.subject.ddc
600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit
dc.title
NLRP3 protects alveolar barrier integrity by an inflammasome-independent
increase of epithelial cell adherence
dc.type
Wissenschaftlicher Artikel
dcterms.bibliographicCitation
Scientific Reports. - 6 (2016), Artikel Nr. 30943
dcterms.bibliographicCitation.doi
10.1038/srep30943
dcterms.bibliographicCitation.url
http://www.nature.com/articles/srep30943
refubium.affiliation
Charité - Universitätsmedizin Berlin
de
refubium.mycore.fudocsId
FUDOCS_document_000000025386
refubium.note.author
Der Artikel wurde in einer Open-Access-Zeitschrift publiziert.
refubium.resourceType.isindependentpub
no
refubium.mycore.derivateId
FUDOCS_derivate_000000006974
dcterms.accessRights.openaire
open access