dc.contributor.author
Grünberg, W.
dc.contributor.author
Hartmann, H.
dc.contributor.author
Burfeind, Onno
dc.contributor.author
Heuwieser, W.
dc.contributor.author
Staufenbiel, R.
dc.date.accessioned
2018-06-08T04:03:16Z
dc.date.available
2014-04-29T17:32:24.100Z
dc.identifier.uri
https://refubium.fu-berlin.de/handle/fub188/16491
dc.identifier.uri
http://dx.doi.org/10.17169/refubium-20672
dc.description.abstract
Hyperkalemia is a common complication in neonatal diarrheic dairy calves and
is corrected by administration of glucose or sodium bicarbonate. Although the
hypokalemic effect of glucose is well established in other species,
controversial results are reported for sodium bicarbonate. Our objective was
to study the effect and mechanism of action of glucose and sodium bicarbonate
on the potassium homeostasis of healthy neonatal dairy calves. Nine healthy
neonatal Holstein-Friesian calves underwent 3 oral treatments with 2L of
NaHCO(3) (150 mmol/L), glucose (300 mmol/L), and glucose+NaHCO(3) solution
(300 mmol/L+150 mmol/L) in randomized order. Blood was obtained before
treatment (T(0)) and at 30-min intervals thereafter. Changes between each time
point and T(0) were determined for all parameters. Urine was collected
volumetrically to determine total renal potassium excretion over an 8-h
posttreatment period. Plasma volume changes were extrapolated from changes in
plasma protein concentration. Treatment and time effects were tested with
repeated-measures ANOVA. Multivariate stepwise regression analysis using dummy
variable coding was conducted to identify associations between changes in
plasma potassium concentration ([K]) and changes in plasma glucose
concentration ([glucose]), blood base excess, and plasma volume. Oral glucose
and sodium bicarbonate treatments decreased [K] by 25 and 19%, respectively,
whereas the combination of both compounds caused an intermediate [K] decline
(22%). For the glucose treatment, the decline in [K] was only associated with
changes in plasma [glucose] (partial R(2)=0.19). In NaHCO(3)-treated calves,
[K] decline was associated with change of extracellular volume (partial
R(2)=0.31) and blood base excess (partial R(2)=0.19). When glucose and
NaHCO(3) were combined, [K] decline was associated with changes in plasma
volume (partial R(2)=0.30), BE (R(2)=0.22), and [glucose] (partial R(2)=0.03).
Our results indicate that glucose lowers plasma [K] mainly through an insulin-
dependent intracellular translocation of K, whereas NaHCO(3) causes
hypokalemia through hemodilution followed by intracellular translocation of K
caused by the strong ion effect. The combination of glucose and NaHCO(3) at
the dosage used in this study does not have an additive hypokalemic effect.
When combined, hemodilution and strong ion effect have the strongest effect on
plasma [K], whereas the insulin-dependent effect of glucose appears to be
blunted.
de
dc.rights.uri
http://jds.fass.org/misc/ifora.shtml
dc.subject.ddc
600 Technik, Medizin, angewandte Wissenschaften::630 Landwirtschaft
dc.title
Plasma potassium-lowering effect of oral glucose, sodium bicarbonate, and the
combination thereof in healthy neonatal dairy calves
dc.type
Wissenschaftlicher Artikel
dcterms.bibliographicCitation
Journal of Dairy Science. - 94(2011), 11, S. 5646–5655
dcterms.bibliographicCitation.doi
10.3168/jds.2011-4510
dcterms.bibliographicCitation.url
http://dx.doi.org/10.3168/jds.2011-4510
refubium.affiliation
Veterinärmedizin
de
refubium.affiliation.other
Tierklinik für Fortpflanzung
refubium.mycore.fudocsId
FUDOCS_document_000000020275
refubium.note.author
DOI auf Verlagsseite falsch angegeben! Hab ihn aber trotzdem erstmal so
eingefügt... Verlags-PDF muss verwendet werden:
http://www.sherpa.ac.uk/romeo/issn/0022-0302/
refubium.resourceType.isindependentpub
no
refubium.mycore.derivateId
FUDOCS_derivate_000000003524
dcterms.accessRights.openaire
open access