dc.contributor.author
Abdelbary, Mohamed M. H.
dc.contributor.author
Wittenberg, Anne
dc.contributor.author
Cuny, Christiane
dc.contributor.author
Layer, Franziska
dc.contributor.author
Kurt, Kevin
dc.contributor.author
Wieler, Lothar Heinz
dc.contributor.author
Walther, Birgit
dc.contributor.author
Skov, Robert
dc.contributor.author
Larsen, Jesper
dc.contributor.author
Hasman, Henrik
dc.contributor.author
Fitzgerald, J. Ross
dc.contributor.author
Smith, Tara C.
dc.contributor.author
Wagenaar, J. A.
dc.contributor.author
Pantosti, Annalisa
dc.contributor.author
Hallin, Marie
dc.contributor.author
Struelens, Marc J.
dc.contributor.author
Edwards, Giles
dc.contributor.author
Böse, R.
dc.contributor.author
Nübel, Ulrich
dc.contributor.author
Witte, Wolfgang
dc.date.accessioned
2018-06-08T03:56:44Z
dc.date.available
2014-11-28T08:19:19.515Z
dc.identifier.uri
https://refubium.fu-berlin.de/handle/fub188/16274
dc.identifier.uri
http://dx.doi.org/10.17169/refubium-20458
dc.description.abstract
In the early 2000s, a particular MRSA clonal complex (CC398) was found mainly
in pigs and pig farmers in Europe. Since then, CC398 has been detected among a
wide variety of animal species worldwide. We investigated the population
structure of CC398 through mutation discovery at 97 genetic housekeeping loci,
which are distributed along the CC398 chromosome within 195 CC398 isolates,
collected from various countries and host species, including humans. Most of
the isolates in this collection were received from collaborating
microbiologists, who had preserved them over years. We discovered 96 bi-
allelic polymorphisms, and phylogenetic analyses revealed that an epidemic
sub-clone within CC398 (dubbed 'clade (C)') has spread within and between
equine hospitals, where it causes nosocomial infections in horses and
colonises the personnel. While clade (C) was strongly associated with S.
aureus from horses in veterinary-care settings (p = 2 × 10(-7)), it remained
extremely rare among S. aureus isolates from human infections.
en
dc.rights.uri
http://creativecommons.org/licenses/by/4.0/
dc.subject.ddc
600 Technik, Medizin, angewandte Wissenschaften::630 Landwirtschaft
dc.title
Phylogenetic Analysis of Staphylococcus aureus CC398 Reveals a Sub-Lineage
Epidemiologically Associated with Infections in Horses
dc.type
Wissenschaftlicher Artikel
dcterms.bibliographicCitation
PLoS ONE. - 9 (2014), 2, Artikel-Nr .e88083
dc.identifier.sepid
39354
dcterms.bibliographicCitation.doi
10.1371/journal.pone.0088083
dcterms.bibliographicCitation.url
http://dx.doi.org/10.1371/journal.pone.0088083
refubium.affiliation
Veterinärmedizin
de
refubium.affiliation.other
Institut für Mikrobiologie und Tierseuchen

refubium.mycore.fudocsId
FUDOCS_document_000000021361
refubium.note.author
Der Artikel wurde in einer Open-Access-Zeitschrift publiziert.
refubium.resourceType.isindependentpub
no
refubium.mycore.derivateId
FUDOCS_derivate_000000004200
dcterms.accessRights.openaire
open access
dcterms.isPartOf.issn
1932-6203