dc.contributor.author
Elkhal, Abdallah
dc.contributor.author
Biefer, Hector Rodriguez Cetina
dc.contributor.author
Heinbokel, Timm
dc.contributor.author
Uehara, Hirofumi
dc.contributor.author
Quante, Markus
dc.contributor.author
Seyda, Midas
dc.contributor.author
Schuitenmaker, Jeroen M.
dc.contributor.author
Krenzien, Felix
dc.contributor.author
Camacho, Virginia
dc.contributor.author
Fuente, Miguel A. de la
dc.contributor.author
Ghiran, Ionita
dc.contributor.author
Tullius, Stefan G.
dc.date.accessioned
2018-06-08T03:55:25Z
dc.date.available
2016-03-29T09:36:40.632Z
dc.identifier.uri
https://refubium.fu-berlin.de/handle/fub188/16214
dc.identifier.uri
http://dx.doi.org/10.17169/refubium-20398
dc.description.abstract
CD4+ CD25+ Foxp3+ Tregs have been shown to play a central role in immune
homeostasis while preventing from fatal inflammatory responses, while Th17
cells have traditionally been recognized as pro-inflammatory mediators
implicated in a myriad of diseases. Studies have shown the potential of Tregs
to convert into Th17 cells, and Th17 cells into Tregs. Increasing evidence
have pointed out CD25 as a key molecule during this transdifferentiation
process, however molecules that allow such development remain unknown. Here,
we investigated the impact of NAD+ on the fate of CD4+ CD25+ Foxp3+ Tregs in-
depth, dissected their transcriptional signature profile and explored
mechanisms underlying their conversion into IL-17A producing cells. Our
results demonstrate that NAD+ promotes Treg conversion into Th17 cells in
vitro and in vivo via CD25 cell surface marker. Despite the reduced number of
Tregs, known to promote homeostasis, and an increased number of pro-
inflammatory Th17 cells, NAD+ was able to promote an impressive allograft
survival through a robust systemic IL-10 production that was CD4+ CD25+ Foxp3+
independent. Collectively, our study unravels a novel immunoregulatory
mechanism of NAD+ that regulates Tregs fate while promoting allograft survival
that may have clinical applications in alloimmunity and in a wide spectrum of
inflammatory conditions.
en
dc.rights.uri
http://creativecommons.org/licenses/by/4.0/
dc.subject.ddc
600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit
dc.title
NAD+ regulates Treg cell fate and promotes allograft survival via a systemic
IL-10 production that is CD4+ CD25+ Foxp3+ T cells independent
dc.type
Wissenschaftlicher Artikel
dcterms.bibliographicCitation
Scientific Reports. - 6 (2016), Artikeol Nr. 22325
dcterms.bibliographicCitation.doi
10.1038/srep22325
dcterms.bibliographicCitation.url
http://www.nature.com/articles/srep22325
refubium.affiliation
Charité - Universitätsmedizin Berlin
de
refubium.mycore.fudocsId
FUDOCS_document_000000024274
refubium.note.author
Der Artikel wurde in einer Open-Access-Zeitschrift publiziert.
refubium.resourceType.isindependentpub
no
refubium.mycore.derivateId
FUDOCS_derivate_000000006192
dcterms.accessRights.openaire
open access