dc.contributor.author
Ielacqua, Giovanna D.
dc.contributor.author
Schlege, Felix
dc.contributor.author
Füchtemeier, Martina
dc.contributor.author
Xandry, Jael
dc.contributor.author
Rudin, Markus
dc.contributor.author
Klohs, Jan
dc.date.accessioned
2018-06-08T03:53:48Z
dc.date.available
2016-02-22T09:18:18.775Z
dc.identifier.uri
https://refubium.fu-berlin.de/handle/fub188/16167
dc.identifier.uri
http://dx.doi.org/10.17169/refubium-20351
dc.description.abstract
Alterations in density and morphology of the cerebral microvasculature have
been reported to occur in Alzheimer's disease patients and animal models of
the disease. In this study we compared magnetic resonance imaging (MRI)
techniques for their utility to detect age-dependent changes of the cerebral
vasculature in the arcAβ mouse model of cerebral amyloidosis. Dynamic
susceptibility contrast (DSC)-MRI was performed by tracking the passage of a
superparamagnetic iron oxide nanoparticle in the brain with dynamic gradient
echo planar imaging (EPI). From this measurements relative cerebral blood
volume [rCBV(DSC)] and relative cerebral blood flow (rCBF) were estimated. For
the same animal maps of the relaxation shift index Q were computed from high
resolution gradient echo and spin echo data that were acquired before and
after superparamagnetic iron oxide (SPIO) nanoparticle injection. Q-values
were used to derive estimates of microvessel density. The change in the
relaxation rates ΔR∗2 obtained from pre- and post-contrast gradient echo data
was used for the alternative determination of rCBV [rCBV(ΔR∗2)]. Linear mixed
effects modeling found no significant association between rCBV(DSC),
rCBV(ΔR∗2), rCBF, and Q with genotype in 13-month old mice [compared to age-
matched non-transgenic littermates (NTLs)] for any of the evaluated brain
regions. In 24-month old mice there was a significant association for
rCBV(DSC) with genotype in the cerebral cortex, and for rCBV(ΔR∗2) in the
cerebral cortex and cerebellum. For rCBF there was a significant association
in the cerebellum but not in other brain regions. Q-values in the olfactory
bulb, cerebral cortex, striatum, hippocampus, and cerebellum in 24-month old
mice were significantly associated with genotype. In those regions Q-values
were reduced between 11 and 26% in arcAβ mice compared to age-matched NTLs.
Vessel staining with CD31 immunohistochemistry confirmed a reduction of
microvessel density in the old arcAβ mice. We further demonstrated a region-
specific association between parenchymal and vascular deposition of β-amyloid
and decreased vascular density, without a correlation with the amount of Aβ
deposition. We found that Q mapping was more suitable than the hemodynamic
read-outs to detect amyloid-related degeneration of the cerebral
microvasculature.
en
dc.rights.uri
http://creativecommons.org/licenses/by/4.0/
dc.subject
Alzheimer's disease
dc.subject
microvessel density
dc.subject
dynamic susceptibilty contrast MRI
dc.subject
relaxation rate shift index
dc.subject
superparamagnetic iron oxide nanoparticles
dc.subject
cerebral amyloidosis
dc.subject
cerebral amyloid angiopathy
dc.subject.ddc
600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit
dc.title
Magnetic Resonance Q Mapping Reveals a Decrease in Microvessel Density in the
arcAβ Mouse Model of Cerebral Amyloidosis
dc.type
Wissenschaftlicher Artikel
dcterms.bibliographicCitation
Front. Aging Neurosci. - 7 (2016), Artikel Nr. 241
dcterms.bibliographicCitation.doi
10.3389/fnagi.2015.00241
dcterms.bibliographicCitation.url
http://journal.frontiersin.org/article/10.3389/fnagi.2015.00241/abstract
refubium.affiliation
Charité - Universitätsmedizin Berlin
de
refubium.mycore.fudocsId
FUDOCS_document_000000023931
refubium.note.author
Der Artikel wurde in einer reinen Open-Access-Zeitschrift publiziert.
refubium.resourceType.isindependentpub
no
refubium.mycore.derivateId
FUDOCS_derivate_000000006012
dcterms.accessRights.openaire
open access