dc.contributor.author
Hillert, Reyk
dc.contributor.author
Gieseler, Anne
dc.contributor.author
Krusche, Andreas
dc.contributor.author
Humme, Daniel
dc.contributor.author
Röwert-Huber, Hans-Joachim
dc.contributor.author
Sterry, Wolfram
dc.contributor.author
Walden, Peter
dc.contributor.author
Schubert, Walter
dc.date.accessioned
2018-06-08T03:53:05Z
dc.date.available
2016-02-26T12:56:48.774Z
dc.identifier.uri
https://refubium.fu-berlin.de/handle/fub188/16137
dc.identifier.uri
http://dx.doi.org/10.17169/refubium-20321
dc.description.abstract
Immune surveillance of tumour cells is an important function of CD8 T
lymphocytes, which has failed in cancer for reasons still unknown in many
respect but mainly related to cellular processes in the tumour
microenvironment. Applying imaging cycler microscopy to analyse the immune
contexture in a human skin cancer we could identify and map 7,000 distinct
cell surface-associated multi-protein assemblies. The resulting combinatorial
geometry-based high-functional resolution led to discovery of a mechanism of T
cell trapping in the epidermis, which involves SPIKE, a network of suprabasal
keratinocyte projections piercing and interconnecting CD8 T cells. It appears
initiated by clusters of infrabasal T and dendritic cells connected via cell
projections across a fractured basal lamina to suprabasal keratinocytes and T
lymphocytes.
en
dc.rights.uri
http://creativecommons.org/licenses/by/4.0/
dc.subject.ddc
600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit
dc.title
Large molecular systems landscape uncovers T cell trapping in human skin
cancer
dcterms.bibliographicCitation
Scientific Reports. - 6 (2016), Artikel Nr. 19012
dcterms.bibliographicCitation.doi
10.1038/srep19012
dcterms.bibliographicCitation.url
http://www.nature.com/articles/srep19012
refubium.affiliation
Charité - Universitätsmedizin Berlin
de
refubium.mycore.fudocsId
FUDOCS_document_000000024029
refubium.note.author
Der Artikel wurde in einer Open-Access-Zeitschrift publiziert.
refubium.mycore.derivateId
FUDOCS_derivate_000000006032
dcterms.accessRights.openaire
open access