dc.contributor.author
Poller, Wolfram C.
dc.contributor.author
Dreger, Henryk
dc.contributor.author
Schwerg, Marius
dc.contributor.author
Melzer, Christoph
dc.date.accessioned
2018-06-08T03:50:09Z
dc.date.available
2015-04-23T10:43:40.166Z
dc.identifier.uri
https://refubium.fu-berlin.de/handle/fub188/16031
dc.identifier.uri
http://dx.doi.org/10.17169/refubium-20217
dc.description.abstract
Aims Optimization of the AV-interval (AVI) in DDD pacemakers improves cardiac
hemodynamics and reduces pacemaker syndromes. Manual optimization is typically
not performed in clinical routine. In the present study we analyze the
prevalence of E/A wave fusion and A wave truncation under resting conditions
in 160 patients with complete AV block (AVB) under the pre-programmed AVI. We
manually optimized sub-optimal AVI. Methods We analyzed 160 pacemaker patients
with complete AVB, both in sinus rhythm (AV-sense; n = 129) and under atrial
pacing (AV-pace; n = 31). Using Doppler analyses of the transmitral inflow we
classified the nominal AVI as: a) normal, b) too long (E/A wave fusion) or c)
too short (A wave truncation). In patients with a sub-optimal AVI, we
performed manual optimization according to the recommendations of the American
Society of Echocardiography. Results All AVB patients with atrial pacing
exhibited a normal transmitral inflow under the nominal AV-pace intervals
(100%). In contrast, 25 AVB patients in sinus rhythm showed E/A wave fusion
under the pre-programmed AV-sense intervals (19.4%; 95% confidence interval
(CI): 12.6–26.2%). A wave truncations were not observed in any patient. All
patients with a complete E/A wave fusion achieved a normal transmitral inflow
after AV-sense interval reduction (mean optimized AVI: 79.4 ± 13.6 ms).
Conclusions Given the rate of 19.4% (CI 12.6–26.2%) of patients with a too
long nominal AV-sense interval, automatic algorithms may prove useful in
improving cardiac hemodynamics, especially in the subgroup of atrially
triggered pacemaker patients with AV node diseases.
en
dc.rights.uri
http://creativecommons.org/licenses/by/4.0/
dc.subject.ddc
600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit
dc.title
Prevalence of E/A Wave Fusion and A Wave Truncation in DDD Pacemaker Patients
with Complete AV Block under Nominal AV Intervals
dc.type
Wissenschaftlicher Artikel
dcterms.bibliographicCitation
PLoS ONE. - 10 (2015), 2, Artikel Nr. e0116075
dcterms.bibliographicCitation.doi
10.1371/journal.pone.0116075
dcterms.bibliographicCitation.url
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0116075
refubium.affiliation
Charité - Universitätsmedizin Berlin
de
refubium.mycore.fudocsId
FUDOCS_document_000000022274
refubium.note.author
Der Artikel wurde in einer Open-Access-Zeitschrift publiziert.
refubium.resourceType.isindependentpub
no
refubium.mycore.derivateId
FUDOCS_derivate_000000004811
dcterms.accessRights.openaire
open access