dc.contributor.author
Dobson, Adam J.
dc.contributor.author
Purves, Joanne
dc.contributor.author
Kamysz, Wojciech
dc.contributor.author
Rolff, Jens
dc.date.accessioned
2018-06-08T03:49:26Z
dc.date.available
2015-11-09T07:02:58.109Z
dc.identifier.uri
https://refubium.fu-berlin.de/handle/fub188/16001
dc.identifier.uri
http://dx.doi.org/10.17169/refubium-20187
dc.description.abstract
With a diminishing number of effective antibiotics, there has been interest in
developing antimicrobial peptides (AMPs) as drugs. However, any new drug faces
potential bacterial resistance evolution. Here, we experimentally compare
resistance evolution in Staphylococcus aureus selected by three AMPs (from
mammals, amphibians and insects), a combination of two AMPs, and two
antibiotics: the powerful last-resort vancomycin and the classic streptomycin.
We find that resistance evolves readily against single AMPs and against
streptomycin, with no detectable fitness cost. However the response to
selection from our combination of AMPs led to extinction, in a fashion
qualitatively similar to vancomycin. This is consistent with the hypothesis
that simultaneous release of multiple AMPs during immune responses is a factor
which constrains evolution of AMP resistant pathogens.
en
dc.rights.uri
http://creativecommons.org/licenses/by/2.0/de/
dc.subject.ddc
500 Naturwissenschaften und Mathematik::570 Biowissenschaften; Biologie
dc.title
Comparing Selection on S. aureus between Antimicrobial Peptides and Common
Antibiotics
dc.type
Wissenschaftlicher Artikel
dcterms.bibliographicCitation
PLoS ONE. - 8 (2013), 10, Artikel Nr. e76521
dcterms.bibliographicCitation.doi
10.1371/journal.pone.0076521
dcterms.bibliographicCitation.url
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0076521
refubium.affiliation
Biologie, Chemie, Pharmazie
de
refubium.mycore.fudocsId
FUDOCS_document_000000023438
refubium.note.author
Der Artikel wurde ine einer Open-Access-Zeitschrift publiziert.
refubium.resourceType.isindependentpub
no
refubium.mycore.derivateId
FUDOCS_derivate_000000005647
dcterms.accessRights.openaire
open access