dc.contributor.author
von Krueger, X.
dc.contributor.author
Scherpenisse, P.
dc.contributor.author
Roiger, S.
dc.contributor.author
Heuwieser, Wolfgang
dc.date.accessioned
2018-06-08T03:47:31Z
dc.date.available
2014-02-18T19:12:06.444Z
dc.identifier.uri
https://refubium.fu-berlin.de/handle/fub188/15940
dc.identifier.uri
http://dx.doi.org/10.17169/refubium-20127
dc.description.abstract
Acute puerperal metritis (APM) is one of the most common diseases during the
puerperal period. Systemic administration of ceftiofur for 5 consecutive days
has been shown to be effective for treatment of APM. The objective of this
study was to determine concentrations of ceftiofur derivatives in serum,
endometrial tissue, and lochia of cows with fever postpartum or APM 4 to 6d
after treatment with a single subcutaneous dose of 6.6 mg of ceftiofur
crystalline free acid (CCFA)/kg of estimated BW at the base of the ear. In the
first experiment, samples from CCFA-treated cows with fever postpartum or APM
(n=42) were taken on d 4, 5, or 6 after treatment. Concentrations of ceftiofur
derivatives were quantified using an HPLC assay. Concentrations of active
ceftiofur metabolite desfuroylceftiofuracetamide (DCA) were greatest at d 4
after treatment with CCFA in all samples, but they were considerably lower
than the concentrations of DCA in healthy postpartum cows treated with the
same dose of CCFA. The concentrations of DCA in serum, endometrial tissue, and
lochia were affected by odor of vaginal discharge before treatment with CCFA.
Mean concentrations of DCA could be detected above the reported minimal drug
concentrations (minimum inhibitory concentrations, MIC) required to inhibit
relevant pathogens such as Escherichia coli and Arcanobacterium pyogenes in
serum on all days and in endometrial tissue and lochia only on d 4 in CCFA-
treated cows with fetid vaginal discharge before treatment. In the second
experiment, samples from CCFA-treated cows with APM (n=8) were taken on d 0
(before treatment) and d 4, 5, and 6 after treatment. Mean concentrations of
DCA in serum and lochia were similar on d 4 to 6 in both laboratories.
Furthermore, determined concentrations of DCA from both laboratories were
correlated for serum and lochia. Mean concentrations of DCA could be detected
above the reported MIC in serum and lochia only on d 4. Our 2 experiments
demonstrated that in postpartum cows with fever postpartum or APM
concentrations above the MIC for relevant bacteria (>0.5 μg/mL or >0.5 μg/g)
of DCA could be sustained only for 4 (serum: 15/17; endometrial tissue: 2/17;
lochia: 1/16) to 5d (serum: 10/13; endometrial tissue: 1/13; lochia: 2/12)
after a single treatment with CCFA only in a certain proportion of cows.
Overall, our data provide first pharmacological evidence that a single
subcutaneous administration of 6.6g of CCFA/kg of BW might not be sufficient
to efficaciously treat APM in postpartum dairy cows.
de
dc.rights.uri
http://www.journalofdairyscience.org
dc.subject.ddc
600 Technik, Medizin, angewandte Wissenschaften::630 Landwirtschaft
dc.title
Determination of ceftiofur derivatives in serum, endometrial tissue, and
lochia in puerperal dairy cows with fever or acute puerperal metritis after
subcutaneous administration of ceftiofur crystalline free acid
dc.type
Wissenschaftlicher Artikel
dcterms.bibliographicCitation
Journal of Dairy Science. - 96 (2013), 2, S. 1054-1062
dc.identifier.sepid
31598
dcterms.bibliographicCitation.doi
10.3168/jds.2012-6034
dcterms.bibliographicCitation.url
http://dx.doi.org/10.3168/jds.2012-6034
refubium.affiliation
Veterinärmedizin
de
refubium.affiliation.other
Tierklinik für Fortpflanzung
refubium.mycore.fudocsId
FUDOCS_document_000000019639
refubium.resourceType.isindependentpub
no
refubium.mycore.derivateId
FUDOCS_derivate_000000003061
dcterms.accessRights.openaire
open access
dcterms.isPartOf.issn
00220302