dc.contributor.author
Hain, Elisabeth G.
dc.contributor.author
Klein, Charlotte
dc.contributor.author
Munder, Tonia
dc.contributor.author
Braun, Juergen
dc.contributor.author
Riek, Kerstin
dc.contributor.author
Mueller, Susanne
dc.contributor.author
Sack, Ingolf
dc.date.accessioned
2018-06-08T03:44:18Z
dc.date.available
2016-09-20T07:50:10.653Z
dc.identifier.uri
https://refubium.fu-berlin.de/handle/fub188/15825
dc.identifier.uri
http://dx.doi.org/10.17169/refubium-20012
dc.description.abstract
The biomechanical properties of brain tissue are altered by histopathological
changes due to neurodegenerative diseases like Parkinson's disease (PD). Such
alterations can be measured by magnetic resonance elastography (MRE) as a non-
invasive technique to determine viscoelastic parameters of the brain. Until
now, the correlation between histopathological mechanisms and observed
alterations in tissue viscoelasticity in neurodegenerative diseases is still
not completely understood. Thus, the objective of this study was to evaluate
(1) the validity of MRE to detect viscoelastic changes in small and specific
brain regions: the substantia nigra (SN), midbrain and hippocampus in a mouse
model of PD, and (2) if the induced dopaminergic neurodegeneration and
inflammation in the SN is reflected by local changes in viscoelasticity.
Therefore, MRE measurements of the SN, midbrain and hippocampus were performed
in adult female mice before and at five time points after
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridin hydrochloride (MPTP) treatment
specifically lesioning dopaminergic neurons in the SN. At each time point,
additional mice were utilized for histological analysis of the SN. After
treatment cessation, we observed opposed viscoelastic changes in the midbrain,
hippocampus and SN with the midbrain showing a gradual rise and the
hippocampus a distinct transient increase of viscous and elastic parameters,
while viscosity and–to a lesser extent—elasticity in the SN decreased over
time. The decrease in viscosity and elasticity in the SN was paralleled by a
reduced number of neurons due to the MPTP-induced neurodegeneration. In
conclusion, MRE is highly sensitive to detect local viscoelastic changes in
specific and even small brain regions. Moreover, we confirmed that neuronal
cells likely constitute the backbone of the adult brain mainly accounting for
its viscoelasticity. Therefore, MRE could be established as a new potential
instrument for clinical evaluation and diagnostics of neurodegenerative
diseases.
en
dc.rights.uri
http://creativecommons.org/licenses/by/4.0/
dc.subject.ddc
600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit
dc.title
Dopaminergic Neurodegeneration in the Mouse Is Associated with Decrease of
Viscoelasticity of Substantia Nigra Tissue
dc.type
Wissenschaftlicher Artikel
dcterms.bibliographicCitation
PLoS ONE. - 11 (2016), 8, Artikel Nr. e0161179
dcterms.bibliographicCitation.doi
10.1371/journal.pone.0161179
dcterms.bibliographicCitation.url
http://dx.doi.org/10.1371/journal.pone.0161179
refubium.affiliation
Charité - Universitätsmedizin Berlin
de
refubium.mycore.fudocsId
FUDOCS_document_000000025395
refubium.note.author
Der Artikel wurde in einer Open-Access-Zeitschrift publiziert.
refubium.resourceType.isindependentpub
no
refubium.mycore.derivateId
FUDOCS_derivate_000000006983
dcterms.accessRights.openaire
open access