dc.contributor.author
Labuz, Dominika
dc.contributor.author
Celik, Melih O.
dc.contributor.author
Zimmer, Andreas
dc.contributor.author
Machelska, Halina
dc.date.accessioned
2018-06-08T03:34:32Z
dc.date.available
2016-10-04T09:24:05.695Z
dc.identifier.uri
https://refubium.fu-berlin.de/handle/fub188/15480
dc.identifier.uri
http://dx.doi.org/10.17169/refubium-19668
dc.description.abstract
Neuropathic pain often results from peripheral nerve damage, which can involve
immune response. Local leukocyte-derived opioid peptides or exogenous opioid
agonists inhibit neuropathy-induced mechanical hypersensitivity in animal
models. Since neuropathic pain can also be augmented by heat, in this study we
investigated the role of opioids in the modulation of neuropathy-evoked heat
hypersensitivity. We used a chronic constriction injury of the sciatic nerve
in wild-type and opioid peptide-knockout mice, and tested opioid effects in
heat and mechanical hypersensitivity using Hargreaves and von Frey tests,
respectively. We found that although perineural exogenous opioid agonists,
including peptidergic ligands, were effective, the endogenous opioid peptides
β-endorphin, Met-enkephalin and dynorphin A did not alleviate heat
hypersensitivity. Specifically, corticotropin-releasing factor, an agent
triggering opioid peptide secretion from leukocytes, applied perineurally did
not attenuate heat hypersensitivity in wild-type mice. Exogenous opioids, also
shown to release opioid peptides via activation of leukocyte opioid receptors,
were equally analgesic in wild-type and opioid peptide-knockout mice,
indicating that endogenous opioids do not contribute to exogenous opioid
analgesia in heat hypersensitivity. Furthermore, exogenously applied opioid
peptides were ineffective as well. Conversely, opioid peptides relieved
mechanical hypersensitivity. Thus, both opioid type and sensory modality may
determine the outcome of neuropathic pain treatment.
en
dc.rights.uri
http://creativecommons.org/licenses/by/4.0/
dc.subject.ddc
600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit
dc.title
Distinct roles of exogenous opioid agonists and endogenous opioid peptides in
the peripheral control of neuropathy-triggered heat pain
dc.type
Wissenschaftlicher Artikel
dcterms.bibliographicCitation
Scientific Reports. - 6 (2016), Artikel Nr. 32799
dcterms.bibliographicCitation.doi
10.1038/srep32799
dcterms.bibliographicCitation.url
http://www.nature.com/articles/srep32799
refubium.affiliation
Charité - Universitätsmedizin Berlin
de
refubium.mycore.fudocsId
FUDOCS_document_000000025471
refubium.note.author
Der Artikel wurde in einer Open-Access-Zeitschrift publiziert.
refubium.resourceType.isindependentpub
no
refubium.mycore.derivateId
FUDOCS_derivate_000000007161
dcterms.accessRights.openaire
open access